均匀试验设计优选产妇康颗粒挥发油的包合工艺  

Optimization of Inclusion Technology for Volatile Oil from Chanfukang Granule by Uniform Design

作　　者：贾永艳[1] 祝侠丽[1] 周红敏[1] 李九席[1] 魏超娟[1] 李翠萍[1] 田效志[1] 

机构地区：[1]河南中医学院,郑州450008

出　　处：《中国实验方剂学杂志》2012年第12期34-37,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：郑州市科技攻关项目(064SGDS33221-3)

摘　　要：目的:优化产妇康颗粒中挥发油的β-环糊精包合工艺。方法:采用饱和水溶液法包合,以挥发油包合率为指标,以β-环糊精与挥发油的比例、包合温度、包合时间为考察因素,采用均匀试验优选包合工艺,并对包合物的物相进行验证。结果:最佳工艺为挥发油与β-CD的比例1∶8,包合温度40℃,包合时间140 min。在该优选条件下,挥发油包合率达75%,验证结果显示包合物已形成。结论:该优选的包合工艺合理、稳定、可行。Objective： To optimize inclusion process of volatile oil from Chanfukang granule. Method： Inclusion process was carried out by saturated aqueous solution method, inclusion process was optimized by uniform design with inclusion ratio of volatile oil as index, taking ratio of volatile oil to β-CD, inclusion temperature and inclusion time as factors, and physical phase of inclusion complex was verified. Result： Optimum inclusion process was as follows： ratio of volatile oil to β-CD 1 ： 8, inclusion temperature 40 ℃ , inclusion time 140 min. Inclusion rate of volatile oil was as high as 75% under these optimized technology conditions. Validation result showed that inclusion compound had been formed. Conclusion： This optimized inclusion process was reasonable, stable and feasible.

关 键 词：产妇康颗粒 挥发油 Β-环糊精包合 均匀试验设计 

分 类 号：R283.6[医药卫生—中药学]