白术、茯苓多糖的体外胃肠道代谢研究  

Metabolism of Atractylodes Rhizome Polysaccharides and Pachyman in Gastrointestinal Tract

作　　者：钟熊[1] 王梦月[1] 彭颖[1] 李晓波[1] 

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《中国实验方剂学杂志》2012年第12期132-135,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30973962)

摘　　要：目的:考察白术、茯苓多糖在胃肠道环境中的代谢情况。方法:白术、茯苓多糖分别与人工胃液、肠液和肠道菌共孵育,采用3,5-二硝基水杨酸法(DNS法)测定多糖的含量变化,考察白术、茯苓多糖在人工胃肠道环境中的代谢以及与肠道菌共孵育的变化。结果:白术、茯苓多糖在人工胃肠道环境中没有明显代谢,而与肠道菌的共孵育过程中则产生显著代谢。结论:白术、茯苓多糖在胃肠道中的代谢主要是在肠道中进行,肠道菌在此过程中发挥着重要作用。Objective： To study the metabolism of Atractylodes Rhizome polysaccharides and pachymaran in gastrointestinal environments. Method： Atractylodes Rhizome polysaccharides and pachymaran were incubated with artificial gastric, intestinal juice and gut flora respectively; the method of 3,5-dinitrosalicylic acid （DNS） was applied to determine the variation of reducing sugar content, which suggested the metabolism of Atractylodes Rhizome polysaccharides and pachyman in gastrointestinal environments. Result： There was no significant metabolism found in artificial gastric juice and intestinal juice, while most of the polysaccharides were greatly reduced in the process of incubating with gut flora. Conclusion： The intestinal tract is the mainly metabolic place for Atractylodes Rhizome polysaccharides and pachyman, and the gut flora plays an important role in the process.

关 键 词：白术多糖 茯苓多糖 胃肠道 代谢 

分 类 号：R285.5[医药卫生—中药学]