六味雪哈片对老龄大鼠抗衰老作用的研究  

The Experiment on Anti-senility Effects of Liuwei Xueha Tablets in Aged Rats

作　　者：李宜平[1] 刘海艳[1] 张晋纲[1] 

机构地区：[1]长春中医药大学药学院,长春130117

出　　处：《中国实验方剂学杂志》2012年第12期255-256,共2页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：吉林省科技发展计划项目(20106042)

摘　　要：目的:观察六味雪哈片对老年大鼠的抗衰老作用及机制研究。方法:15月龄大鼠40只均匀分为溶剂对照组、六味雪哈片低剂量组(0.36 g.kg-1)、中剂量组(0.72 g.kg-1)和高剂量组(1.44 g.kg-1)4组,连续ig 60 d后观察对动物体重增长、肝组织超氧化物岐化酶(SOD)活性、血清丙二醛(MDA)含量、血清谷胱甘肽过氧化物酶(GSH-Px)活性的影响。结果:六味雪哈片对动物体重增长和肝匀浆SOD活性无显著影响,但能显著降低血清MDA含量和提高血清GSH-Px活性。结论:六味雪哈片具有延缓衰老作用,其作用机制可能与其清除自由基、减少过氧化脂质的生成有关。Objective： To study the anti-senility effects of Liuwei Xueha tablets in aged rats in order to provide clinical ＆ medicinal basis for its application in weak ＆ elderly patients. Method： Fourty 15-month-old rats were divided into 4 groups at random： the control group and Liuwei Xueha tablets groups, low （ 0.36 g ·kg^-1 ） , middle （0.72 g·kg^-1 ） and high dosages （ 1.44 g ·kg^-1 ） , all groups were orally treated for 60 days. The effects on the rat weight indexes, superoside dismutase （SOD） activities in liver, the malandialdehyde （MDA） contents and glutathione peroxidase （GSH-Px） activities in serum were observed. Result： The tablets showed no obvious effects on elder female rats＇ weight and ascending SOD activities, but it had clear effects of lowering MDA content and raising GSH-Px activities. Conclusion： Liuwei Xueha tablets has anti-senility effects, which may be related with its functions of radicals scavenging and MDA contents decreasing.

关 键 词：六味雪哈片 超氧化物岐化酶 血清丙二醛 谷胱甘肽过氧化物酶 

分 类 号：R285.5[医药卫生—中药学]