退白汤联合窄谱中波紫外线治疗白癜风的对照研究  

Efficiency of Tuibai Decoction Combined with NB-UVB Irradiation in Treating Vitiligo

作　　者：谢勇[1] 盛国荣[1] 顾锐龙[1] 

机构地区：[1]江苏省南通市皮肤病性病防治所,江苏南通226006

出　　处：《中国实验方剂学杂志》2012年第12期266-269,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：南通市指令性社会发展科技计划项目(S2009047)

摘　　要：目的:研究退白汤内服联合窄谱中波紫外线(NB-UVB)局部照射治疗白癜风的有效性和安全性。方法:将入选的137例白癜风患者分为3组。治疗组46例,内服退白汤,2次/d,予NB-UVB局部照射,初始剂量为0.5 J.cm-2,2次/周,每次剂量递增10%～20%,至出现红斑时维持治疗,疗程3月;对照Ⅰ组46例,仅内服退白汤;对照Ⅱ组45例,仅NB-UVB照射,疗程均为3月。结果:治疗组、对照Ⅰ组、对照Ⅱ组的有效率分别为73.91%,52.17%,48.89%,治疗组与对照Ⅰ组、对照Ⅱ组比较,差异均有统计学意义(P<0.05),对照Ⅰ组和对照Ⅱ组比较差异无统计学意义;治疗组中头面部有效率显著优于躯干部和四肢,差异均有统计学意义(P<0.01);治疗组起效时间明显短于对照Ⅰ组、对照Ⅱ组,差异均有统计学意义(P<0.01),对照Ⅰ组与对照Ⅱ组比较,差异无统计学意义。结论:退白汤联合NB-UVB治疗白癜风疗效显著,值得推广使用。Objective： To determine the clinical efficacy and safety of Tuibai decoction combined with NB-UVB irradiation in treating vitiligo. Method： One hundred and thirty-seven patients with vitiligo were divided into 3 groups. In treating group with 46 cases, Tuibai decoction was orally given twice a day, 200 mL per time, and combined with NB-UVB irradiation twice a week with an initiated dose of 0.5 J · cm-2, and increasing the dose with 10%-20% per time till the erythema appeared with 3 month treating course. In control group I with 46 cases, only taken tuibai decoction. In control group II with 45 eases, only NB-UVB irradiation was applied for 3 month treating course. Result： The efficiency in treatment group, the control group I , the control group II was 73.91% , 52.17% , 48.89% , respectively. The difference between the treatment group and the two control groups was statistically significant （P 〈 0.05） , and the difference between the control group I and 11 wa not statistically significant, efficiency of the head and face was remarkably higher than that of the trunk and extremities （P 〈 0.01）. The onset time of the treatment group was significantly shorter than that in control groups, and the difference was statistically significant （P 〈 0.01 ） , but the control group I compared with control group, II , the difference was not statistically significant. Conclusion： Tuibai decoction combined with NB-UVB irradiation is clinically effective and safe in treating vitligo.

关 键 词：白癜风 退白汤 窄谱中波紫外线 临床疗效 

分 类 号：R287[医药卫生—中药学]