冠状动脉病变与血浆氧化低密度脂蛋白的相关性研究  

A Study on Serum Oxidized Low-density Lipoprotein in Patients with Coronary Artery Disease

作　　者：唐庆[1] 李茜[1] 赵伊婷[1] 白利萍 刘世豫[1] 

机构地区：[1]新疆医科大学第六附属医院,乌鲁木齐830002 [2]北京万全药业有限公司,北京100097

出　　处：《中国实验方剂学杂志》2012年第12期282-285,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨冠心病患者氧化型低密度脂蛋白(ox-LDL)的变化,评估ox-LDL水平检测的临床意义。方法:采用ELISA法测定139例冠心病患者〔急性冠状动脉综合征(ACS)103例,非ACS组86例〕和210例健康对照组人群血浆ox-LDL水平;根据冠状动脉造影结果将冠心病组分为多支病变组、双支病变组和单支病变组进行比较分析。结果:ACS组患者和非ACS组患者ox-LDL水平均显著高于健康对照组[ACS组为(185.44±70.11)mg.L-1,非ACS组(139.51±58.790)mg.L-1,对照组为(80.47±25.96)mg.L-1,P均<0.001];且ACS组患者ox-LDL水平显著高于非ACS组(P<0.001)。冠状动脉多支、双支、单支病变组ox-LDL水平分别为(180.34±76.92),(149.18.15±64.80),(137.74±58.09)mg.L-1,多支高于单支(P<0.01)。多因素分析显示冠状动脉病变程度仅与ox-LDL相关(R2=0.046,β=0.208,P=0.000)。结论:冠心病患者ox-LDL水平升高与病变程度相关,急性冠脉综合征患者变化尤为明显。Objective： To investigate the changes in plasma oxidized low-density lipoprotein （ox-LDL） in the patients with coronary heart disease, and to evaluate the clinical value of detection for ox-LDL level. Method： Enzyme-linked immunosorbent assay （ELISA） was used to measure the plasma ox-LDL in 189 patients with coronary heart disease, among them 103 were acute coronary syndrome （ACS） and 86 were non-ACS patients, and in additional 210 healthy controls. The patients were divided by coronary angiography into multivessel disease group, double-vessel group and mono-vessel disease group. Result： The ox-LDL levels of the patients in both ACS and non-ACS groups [ （ 185.44 ±70. 11 ）, （ 139.51±58. 790） mg·L^-1] were siginificantly higher than that in normal controls group [ （80.47± 25.96 mg·L^-1 ], （P 〈 0. 001 ）, and the ox-LDL level of patients in ACS group was siginificantly higher than that in non-ACS group （P 〈 0. 001）. Different plasma levels of ox-LDL were found in the multi-vessel, double-vessel and mono-vessel disease group, [ （ 180.34 ± 76.92） , （149.18.15 ±64.80）, （ 137.74 ± 58.09） mg·L^-1]. The ox-LDL levels in multi-vessel disease group were siginificantly higher than that in mono-vessel group （P 〈 0.01 ）. Multiple linear regression analysis showed that ox-LDL levels Siginificantly correlated with the sevesity of coronary artery disease （R2 = 0. 046, β = 0. 208, P = 0. 000）. Conclusion： Elevated ox-LDL presented in patients with coronary heart disease is correlated with the severity coronary artery lesion, especially in the patients with acute coronary syndrome.

关 键 词：氧化型低密度脂蛋白 急性冠状动脉综合征 冠状动脉造影 

分 类 号：R287[医药卫生—中药学]