微透析技术在脑内药物代谢动力学及脑缺血研究中的应用  

Application of Microdialysis in Brain Pharmacokinetics and Cerebral Ischemia Studies

作　　者：吉恋英[1] 杨志宏[1] 孙晓波[1] 

机构地区：[1]中国医学科学院药用植物研究所,北京100193

出　　处：《中国实验方剂学杂志》2012年第12期303-307,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(8110287);高等学校博士学科点专项科研基金(20101106120049);国家科技支撑计划课题(2008BAI51BOO)

摘　　要：介绍微透析技术在脑内药物代谢动力学研究及脑缺血研究中的应用。主要从药物跨越血脑屏障特性、药物转运、药物在脑内不同区域分布,以及神经递质和能量代谢产物变化、外源性药物的脑保护作用等方面,来介绍微透析技术在脑内药物代谢动力学研究及脑缺血研究中的应用。微透析技术能够实现对脑特定部位细胞外液中的内源性及外源性化合物的持续检测及动态观察,是脑内药代动力学、脑缺血研究的重要手段,具有独特的优势及广阔的应用前景。The applications of brain microdialysis in pharmacokinetics in the normal brain and cerebral ischemia model were chiefly introduced. The applications include the drugs across the blood-brain barrier characteristics, drug transport, the distribution of drugs in different regions in the brain, the changes of neurotransmitters and energy metabolites, and cerebral protective effect of exogenous drugs, etc. Brain microdialysis technique can collect samples from extracellular fluid of the endogenous and exogenous compounds in the specific site continuously, and the samples can be dynamically sampled and observed. The technique has become an important research tool and presents unique advantages and prod perspective in pharmacokinetics in the normal brain and cerebral ischemia model.

关 键 词：微透析 脑内研究 药物代谢动力学 脑缺血 

分 类 号：R285[医药卫生—中药学]