益气化瘀汤对早期糖尿病肾病细胞因子水平干预的研究  

Study on Intervention Effect of Yiqi Huayu Decoction on the Cell Factor Levels in Early Diabetic Nephropathy

作　　者：叶赏和[1] 潘兴成 胡国华[2] 石森林[3] 葛卫红[3] 

机构地区：[1]金华市人民医院,浙江金华321000 [2]金华职业技术学院医学院,浙江金华321000 [3]浙江中医药大学药学院,浙江杭州310053

出　　处：《中华中医药学刊》2012年第6期1236-1238,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81173160);浙江省钱江人才计划资助项目

摘　　要：目的:探讨益气化瘀汤对早期糖尿病肾病(DN)血细胞因子的影响。方法:将105例早期糖尿病肾病随机分为对照组(50例)与观察组(55例)。对照组用洛汀新片:10mg/次,1次/日,口服;观察组在对照组基础上加用益气化瘀汤每天1剂,8周为1疗程。治疗前后检测血白介素(IL-8)、IL-18、肿瘤生长因子a(TNF-a)水平。并附50例健康对照组。结果:两组治疗前炎性细胞因子比较差异无统计学意义(P>0.05),但明显高于健康组(P<0.01);观察组自身治疗前后细胞因子水平比较均明显下降(P<0.01);治疗后两组比较,差异有统计学意义(P<0.01)。结论:IL-8、IL-18、TNF-a与糖尿病肾病的发生发展相关,益气化瘀汤可能在抑制早期糖尿病肾病发展过程中起着积极的作用。Objective：To explore the effect of Yiqi Huayu decoction on the blood cell factors in early diabetic nephropathy（EDN）.Method：105 patients of END were randomly divided into control group（50 cases）and treatment group（55 cases）.The control group was treated with lotensin of 10mg/time,once a day by oral intake;on the basis of control group,the treatment group was added with the Yiqi Huayu decoction,1 agent a day,8 weeks was a period of treatment.Interleukin（IL-8）,IL-18 and tumor growth factor α（TNF-α）levels in blood were tested before and after the treatment.50 cases of health control were also included.Result：Before treatment,there was no significant statistical difference of inflammatory cells factor between two groups（P0.05）,however,both were significantly higher than that in health group（P0.01）.The cell factor levels declined significantly before and after the treatment in treatment group（P0.01）.After treatment,there was significant statistical difference between two groups（P0.01）.Conclusion：IL-8,IL-18 and TNF-α were associated with the development of diabetic nephropathy,and Yiqi Huayu decoction may play a positive role to inhibit the development process in early diabetic nephropathy.

关 键 词：益气化瘀汤 糖尿病肾病 早期 细胞因子 

分 类 号：R285.5[医药卫生—中药学]