补康灵预防非小细胞肺癌化疗后白细胞减少症的疗效观察  

Clinical Observation of Bukangling on Preventing Leucopenia of NSCLC Caused by Chemotherapy

作　　者：张锦林[1] 倪美鑫[1] 顾海娟[1] 杨磊[1] 王建红[1] 

机构地区：[1]南通大学附属肿瘤医院,江苏南通226361

出　　处：《中华中医药学刊》2012年第6期1315-1316,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省卫生厅医学科技发展基金资助项目(P200939)

摘　　要：目的:观察补康灵预防非小细胞肺癌患者化疗后白细胞减少症的疗效。方法:将120例非小细胞肺癌初治患者随机分为两组,治疗组63例,采用TP方案化疗,联合口服补康灵治疗;对照组57例仅采用TP方案化疗,观察化疗期间两组白细胞的变化、重组人粒细胞集落刺激因子(G-CSF)使用量、白细胞减少继发感染发生情况及生活质量评分情况。结果:治疗组在化疗过程中白细胞减少20例(31.75%)明显少于对照组34例(59.65%)(P<0.05),两组G-CSF用量、生活质量改善状况以及白细胞减少继发感染发生例数之间的均有统计学差异(P<0.05)。结论:补康灵可有效预防非小细胞肺癌化疗所发生的白细胞减少症。Objective： To observe the effect and adverse reaction of Bukangling on preventing leucopenia of NSCLC caused by chemotherapy. Methods ： 120 patients were randomized into two groups ： the treatment group （ 63 cases） were treated with TP chemotherapy and Bukangling while the control group（57 cases）treated with TP chemotherapy only. Dur- ing chemotherapy, the patients were evaluated on situations of WBC, the volume of G - CSF, the secondary infection asso- ciated with leucopenia and score of life - quality in two groups. Results ： Leucopenia patients in treatment group were nota- bly lower than that in control group [ 20 cases （31.75%）vs 34 cases （59.65%） ], the difference in the volume of G - CSF, the secondary infection associated with leucopenia and score of life - quality in two groups were statistically signifi- onnt（ P 〈＇D D~＇~ C,3nelrL.~i,3n. Ruknn~,lin~ i~ nn ~ffe^etivf~ dru~ used in nreventin~ leuconenia caused hv chemotheranv.

关 键 词：补康灵 非小细胞肺癌 化疗 白细胞减少 

分 类 号：R285.6[医药卫生—中药学]