乐胃饮对慢性萎缩性胃炎大鼠AQP3、AQP4蛋白表达的影响  

Effect of Leweiyin on the Expression of Aquaporin3 and Aquaporin4 in Rats with Chronic Atrophic Gastritis

作　　者：吴晋兰[1] 杨伟莲[1] 朱飞叶[2] 陈展[1] 夏露露[1] 

机构地区：[1]杭州市余杭区第五人民医院内科,浙江杭州311100 [2]浙江中医药大学,浙江杭州310053

出　　处：《中华中医药学刊》2012年第6期1335-1336,I0014,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：杭州市余杭区科技计划项目(2008014)

摘　　要：目的:观察乐胃饮对慢性萎缩性胃炎大鼠胃黏膜AQP3、AQP4蛋白表达的影响。方法:60只Wistar大鼠,随机分为正常对照组、模型组、维酶素组、乐胃饮低、中、高剂量组,除正常对照组外,其余大鼠用2%水杨酸钠灌胃、自由饮用MNNG溶液结合饥饱失常等综合因素诱发慢性萎缩性胃炎模型。造模后各组予以灌胃治疗4周。结果:与模型对照组比较,乐胃饮各剂量组胃黏膜AQP3、AQP4蛋白表达显著升高(P<0.01或P<0.05)。结论:乐胃饮可增强慢性萎缩性胃炎大鼠胃黏膜AQP3、AQP4蛋白的表达,可能通过改善胃黏膜水盐代谢,调节胃酸分泌,进而达到治疗CAG的作用。Objective ： To observe the effect of Leweiyin on the expression of AQP3 and AQP4 in rats with chronic a- trophic gastritis. Method ：60 Wistar rats were randomly divided into 6 groups ： normal control group, model group, Weimei- su group, Leweiyin with low - dose, medium - dose and high - dose group. Except the normal control group, the rest five groups of chronic atrophic gastritis model were induced by administering intragastrically with 2% sodium salicylate, a free drink with MNNG solution and a combination of other factors such as irregular diet. Afterwards, corresponding medication was administered to each group for 4 weeks. Results ： Compared to the model group, the expression of AQP3 and AQP4 in each dose of Leweiyin groups significantly higher（P 〈0.01 or P 〈0.05 ） Conclusion：Leweiyin could increase the expres- sion of AQP3 and AQP4 in gastric mucosa of rats with chronic atrophic gastritis. It could treat chronic atrophic gastritis by improving water and salt metabolism in gastric mucosa and regulating gastric acid secretion.

关 键 词：乐胃饮 慢性萎缩性胃炎 AQP3 AQP4 

分 类 号：R285.5[医药卫生—中药学]