黄连解毒汤拮抗脑梗塞急性期大鼠胃黏膜损害的电镜观察  

Electron Microscope Observation of the Effects of Huanglian Jiedu Decoction on Gastric Mucosal Lesions in Acute Cerebral Infarction Rats

作　　者：杨秀丽[1,2] 吴天慧[3] 唐晓晓[3] 王尚书[3] 唐明 

机构地区：[1]青岛市海慈医疗集团,青岛266033 [2]山东中医药大学中医学博士后流动站,济南250355 [3]山东中医药大学,济南250355

出　　处：《中华中医药学刊》2012年第6期1365-1367,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:研究黄连解毒汤(Huanglian Jiedu Decoction,HJD)拮抗脑梗塞急性期大鼠胃黏膜损害的超微结构改变。方法:采用线栓法制备大脑中动脉闭塞局灶性脑缺血大鼠模型,将所有大鼠分为6组:正常对照组、假手术组、脑梗塞组、西咪替丁组、HJD高剂量(10.78g/kg)组、HJD低剂量(5.39g/kg)组,观察大鼠行为学改变,每日1次连续灌胃4天后处死大鼠,分离胃组织进行电镜观察。结果:与正常对照组及假手术组相比,脑梗塞大鼠的胃黏膜结构出现明显的组织破坏,HJD与西米替丁均能减轻上述组织破坏,且HJD的疗效优于西米替丁(P<0.05或P<0.01)。结论 HJD能够部分拮抗急性脑梗塞导致的胃黏膜损害。Objectives ： To observe the uhrastructural changes under the effects of Huanglian Jiedu Decoction （HJD） on gastric mucosal lesions in acute cerebral infarction rats. Methods ： The focal cerebral ischemia rats model were induced by intraluminal middle cerebral artery occlusion. All rats were randomly divided into 6 groups： normal control group, sham- operated group, cerebral Infarction group, cimetidine group,high -dose HJD （10.78g · kg-1）group and low - dose HJD （5.39g · kg-1） group. Behavioral changs were evaluated. All rats were killed after gavage once a day for 4 days. Then the gastric mucosa of these animals were examined with scanning electron microscope. Results： Compared with normal control group and sham -operated group, pathological changes in gastric mucosa were found. HDJ and cime- tidine could ameliorate the gastric mucosal lesions, and the curative effects of HJD were much better than those of cimeti- dine. Conclusions： HJD can partly antagonize gastric mucosal lesions caused by acute cerebral Infarction.

关 键 词：黄连解毒汤 脑梗塞 胃黏膜 电镜 大鼠 

分 类 号：R285.5[医药卫生—中药学]