新型生物可降解聚合物雷帕霉素靶向洗脱支架预防支架内狭窄的动物实验研究  

The Experimental Study in a Novel Targeting Sirolimus-Eluting Stents With Biodegradable Polymer for Preventing In-Stent Stenosis in Porcine Model

作　　者：邱洪[1] 罗彤[1] 胡小莹[1] 吴超[1] 杨跃进[1] 高润霖[1] 唐智荣 阮英茆[3] 徐新林[3] 褚雁[3] 袁卫民[4] 田毅[4] 周燕文[4] 孟亮[4] 唐跃[4] 

机构地区：[1]中国医学科学院 北京协和医学院心血管病研究所 阜外心血管病医院冠心病诊治中心,北京市100037 [2]上海微创医疗器械(上海)有限公司,201203 [3]中国医学科学院 北京协和医学院心血管病研究所 阜外心血管病医院病理与生理实验中心,北京市100037 [4]中国医学科学院 北京协和医学院心血管病研究所 阜外心血管病医院动物实验中心,北京市100037

出　　处：《中国循环杂志》2012年第3期220-223,共4页Chinese Circulation Journal

摘　　要：目的:评价新型的生物可降解聚合物雷帕霉素靶向洗脱支架—Firehawk在小型猪冠状动脉模型预防支架内狭窄的疗效。方法:将Firehawk支架(Firehawk组,n=10)和采用永久聚合物涂层雷帕霉素洗脱支架Firebird 2(Firebird 2组,n=8)置入健康小型猪冠状动脉。术后4周时测定两组支架血管段的平均内膜厚度、新生内膜面积、面积狭窄百分比等参数,以比较其内膜增生的情况。结果:术后4周,Firehawk组和Firebird 2组平均内膜厚度分别为(0.15±0.10)mm和(0.14±0.06)mm,新生内膜面积分别为(1.12±0.57)mm2和(1.04±0.36)mm2,面积狭窄百分比分别为(24.58±14.85)%和(26.80±10.64)%,差异均无统计学意义(P均>0.05)。两组均无支架内狭窄发生。结论:Firehawk支架可有效抑制支架置入后4周时的内膜增生,预防冠状动脉实验性支架内狭窄,效果与传统的永久聚合物涂层药物洗脱支架相当。长期效果有待进一步观察。Objective ：To assess the efficacy of a novel targeting sirolimus-eluting stents with biodegradable polymer-Firehawk stems for preventing in-stent stenosis in a porcine model. Methods ： Our experiment included two groups, Firehawk stents group, n = 10, and Firebird 2 stents （ permanent polymer- coated sirolimus-eluting stents） group, n = 8. Two kinds of stents were respectively implanted into the coronary artery in mini porcine. The average of neointimal thickness, neointimal area and the percentage of area stenosis were examined at 4 weeks after the implantation in both groups. Results ：4 weeks after the implantation, Firehawk stents group and Firebird 2 stents group presented the average neointimal thickness as （0. 15 ±0. 10 ） mm vs. （0. 14 ±0. 06 ） mm, neointimal area as （ 1.12 ± 0. 57 ） mm^2 vs. （ 1.04 ± 0. 36 ）mm^2 and the percentage of area stenosis as （ 24. 58 ± 14. 85 ） % vs. （ 26. 80± 10. 64） % , P〉0. 05 respectively. There was no in-stent stenosis found in neither group. Conclusion：Firehawk stents may effectively inhibit the neointimal proliferation and prevent the in-stent stenosis as the traditional polymer-coated drug-elufing stents in porcine at 4 weeks after the implantation. Two kinds of stents demonstrated good bio- compatibility, and the long-term efficacy should be further studied.

关 键 词：再狭窄 药物洗脱支架 生物可降解聚合物 

分 类 号：R541[医药卫生—心血管疾病]