非ST段抬高心肌梗死和不稳定心绞痛患者血浆脂肪激素Chemerin水平及其影响因素研究  

Plasma Chemerin Levels in Patients with Non-ST Segment Myocardial Infarction/Unstable Angina and Its Influencing Factors

作　　者：范书英[1] 于长安[1] 黎娜[1] 郑金刚[1] 彭文华[1] 陈莉[1] 车勇[1] 赵霞[1] 赵桂茹[1] 王丹[1] 王勇[1] 

机构地区：[1]中日友好医院心内科,北京市100029

出　　处：《中国全科医学》2012年第17期1945-1948,共4页Chinese General Practice

摘　　要：目的探讨非ST段抬高性心肌梗死和不稳定心绞痛(NSTEMI/UA)患者血浆脂肪激素Chemerin水平及其影响因素。方法收集因胸痛住院并行冠状动脉造影的患者121例,根据患者的临床表现和冠状动脉造影结果分组:对照组44例、稳定冠心病组40例和NSTEMI/UA组37例。空腹抽血,测定血浆脂肪激素Chemerin水平及其他生化指标,如空腹血糖、血脂、肌酐、超敏C反应蛋白(hs-CRP)、白细胞、血浆纤维蛋白原等水平。结果与对照组和稳定性冠心病组比较,NSTEMI/UA组血浆脂肪激素Chemerin水平升高〔(229.45±25.47)ng/ml、(203.82±9.89)ng/ml和(214.53±12.24 ng/mL)ng/ml,P<0.05〕。Pearson相关分析表明血浆脂肪激素Chemerin水平与入院时心率、白细胞总数、中性粒细胞、hs-CRP、纤维蛋白原、空腹血糖、肌酐呈正相关关系(r值分别为0.605、0.583、0.610、0.608、0.553、0.558和0.674,P<0.001)。结论 NSTEMI/UA患者血浆脂肪激素Chemerin水平明显升高,并与入院时心率、白细胞、中性粒细胞、hs-CRP、纤维蛋白原、空腹血糖和肌酐水平密切相关,提示Chemerin可能与不稳定斑块和继发血栓形成有关。Objective To examine the plasma chemerin levels in patients with non-ST segment myocardial infarction/unstable angina（NSTEMI/UA） and its influencing factors.Methods The subjects were divided into three groups according to coronary angiography and the clinical presentation：control group（n=44）,stable coronary heart disease group（n=40）,and NSTEMI/UA group（n=37）.Plasma chemerin level was detemined by ELISA;meanwhile,free blood glucose（FBG）,blood lipids,cretinine（Cr）,high-sensitivity C-reactive protein（hs-CRP）,white blood cell（WBC）,plasma fibrinogen and other factors were also analyzed.Results Compared with the control group and stable coronary heart disease group,NSTEMI/UA group has significantly higher plasma chemerin level（（229.45±25.47） ng/ml,（203.82±9.89） ng/ml,（214.53±12.24） ng/ml,P0.05）.Pearson analysis demonstrated that plasma chemerin level was positively correlated with heart rate（HR）,WBC,neutrophil,hs-CRP,fibrinogen,FBG,and Cr（r= 0.605,0.583,0.610,0.608,0.553,0.558 and 0.674,P0.001）.Conclusion Plasma chemerin level is significantly elevated in NSTEMI/UA patients and is correlated with HR,SBP,WBC,neutrophil,hs-CRP,fibrinogen,FBG,and Cr.Chemerin may be associated with atherosclerotic vulnerable plaque and play a role in thrombosis.

关 键 词：CHEMERIN 非ST段抬高性心肌梗死 心绞痛 

分 类 号：R541.42[医药卫生—心血管疾病]