盐酸氨溴索注射液静脉滴注联合硫酸沙丁胺醇和布地奈德雾化吸入治疗慢性阻塞性肺疾病急性加重的疗效观察  

Effect of Ambroxol Hydrochloride Intravenous Drip Combined with Ventolin and Budesonide Aerosol Inhalation on Acute and Exacerbated Chronic Obstruction Pulmonary Disease

作　　者：陈倩[1] 安晓洁[1] 陈峰[1] 胡卫民[1] 刘盛辉[1] 

机构地区：[1]北京市房山区良乡医院急诊科,102401

出　　处：《中国全科医学》2012年第17期1990-1992,共3页Chinese General Practice

摘　　要：目的探讨盐酸氨溴索注射液静脉滴注,联合硫酸沙丁胺醇、布地奈德雾化吸入辅助治疗慢性阻塞性肺疾病急性加重(AECOPD)的临床疗效。方法将60例AECOPD肺功能损伤分级Ⅱ级患者随机分为治疗组30例,对照组30例。对照组给予吸氧、规范抗感染、解痉平喘祛痰等常规治疗。治疗组在对照组的基础上,予硫酸沙丁胺醇2 ml,布地奈德0.5 ml雾化吸入治疗。两组祛痰药均选用盐酸氨溴索30 mg静脉滴注,3次/d。两组疗程均为7 d,治疗后观察并比较两组的临床疗效、急性呼吸困难缓解时间和平均住院天数。结果治疗后,治疗组显效17例,有效10例,无效3例;对照组显效8例,有效19例,无效3例,两组疗效间差异有统计学意义(u=328.5,P=0.046)。急性呼吸困难缓解时间治疗组少于对照组,差异有统计学意义〔(4.30±1.39)d和(5.73±2.08)d,P<0.05〕,住院天数治疗组也少于对照组,差异有统计学意义〔(8.70±3.17)d和(12.16±3.97)d,P<0.05〕。结论氨溴索静脉滴注联合沙丁胺醇、布地奈德氧雾化吸入辅助治疗AECOPD疗效显著,操作简便,临床症状改善快,能缩短患者的住院时间。Objective To discuss the clinical effects of ambroxol hydrochloride combined with ventolin and budesonide aerosol inhalation on acute exacerbations of chronic obstructive pulmonary disease（AECOPD）.Methods Sixty AECOPD patients with Ⅱ degree pulmonary function were randomly divided into groups control（n=30,received conventional treatment such as oxygen uptaking,anti-infection drug etc.） and treatment（n=30,given ventolin and Budesonide aerosol inhalation based on conventional）.Both groups were treated with ambroxol,30 mg,iv gtt,3 times/d,7 d.The clinical effects,clinical remission time of acute dyspnea and hospital stay were observed after therapy.Results After treatment,marked effect was noted in 17 cases,effect in 10 and no effect in 3 in treatment group,while 8,19,3 in control group,respectively.The difference was significant（u=328.5,P=0.046）.The clinical remission time of acute dyspnea significantly shorter in treatment group than in control（（4.30±1.39）d vs（5.73±2.08）d,P0.05）,hospital stay significantly shorter（（8.70±3.17）d vs（12.16±3.97）d,P0.05）.Conclusion Intravenous ambroxol hydrochloride combined with ventolin and budesonide aerosol inhalation has marked effects on AECOPD,with short remission time and hospital stay.

关 键 词：盐酸氨溴索 硫酸沙丁胺醇 布地奈德 肺疾病 慢性阻塞性 急性发作 治疗结果 

分 类 号：R563[医药卫生—呼吸系统]