糖化血红蛋白检测的局限性  

The detection of hemoglobin Alc in clinical application

作　　者：李娅[1] 宋宇[1] 段勇[1] 

机构地区：[1]昆明医学院第一附属医院检验科,650032

出　　处：《中华检验医学杂志》2012年第6期501-504,共4页Chinese Journal of Laboratory Medicine

摘　　要：HbA1c测定结果能够反映患者最近2～3个月内的平均血糖水平，其临床应用价值正从“评估指标”向“诊断指标”转变。由于HbA1c检测受多种因素影响，其标准化进程在我国起步较晚，“切点”问题以及HbA1c在分子水平存在“缺陷”等，限制了HbA1c作为糖尿病诊断指标的应用。因此，阐明HbA1c在实际应用中的局限性对于其更好地应用于临床具有重要的意义。The hemoglobin Alo （HbAlo） results can reflect the average level of blood glucose over the past 2-3 months, its clinical application value is transforming from evaluation indicator to diagnosis indicator. The application of HbAlo as a diagnostic indicator of diabetes is limited by many factors, such as muhi-factor influence on measurement and its late start on standardization process in our country, optimal cut-point and the defect of HbAlc existing in the molecular level, etc. Therefore, clarifying the limitations of HbAlc in the practical application is of great significance for its clinical application.

关 键 词：糖尿病 血红蛋白A 糖基化 

分 类 号：R587.1[医药卫生—内分泌]