甲型H1N1流感疫苗血清抗体消长研究  

Rise and fall of serum HI antibody induced by 2009 influenza A(H1N1) vaccine

作　　者：郑奎城[1,2,3] 沈晓娜[1,2] 杨式芹[1] 周朝晖[1] 谢剑锋[1] 陈炜[1] 翁育伟[1] 严延生[1] 

机构地区：[1]福建省疾病预防控制中心,福州350001 [2]福建医科大学公共卫生学院,福州350004 [3]福建省人兽共患病研究重点实验室,福州350001

出　　处：《中国人兽共患病学报》2012年第6期566-569,573,共5页Chinese Journal of Zoonoses

基　　金：国家传染病防治科技重大专项"突发传染病病原体快速检测与现场机动采样技术平台研究"(2009ZX10004-106)资助~~

摘　　要：目的了解甲型H1N1流感疫苗接种后血清抗体的消长规律,为免疫策略提供依据。方法对128名接种甲型H1N1流感疫苗的研究对象在接种后的第3、6、9、12个月采集血清标本,以血凝抑制试验方法(HI)检测血清HI抗体。结果 128名对象在接种疫苗后的第3、6、9、12个月抗体阳性率和几何平均滴度(GMT)分别为61.7%和40;47.7%和28.4;40.9%和24.5;35.43%和23.6,差异有显著统计学意义(P<0.01)。不论男女,抗体阳性率和GMT均随时间推移显著降低(P<0.01)。不同年龄组的抗体GMT也显著下降(P<0.01)。79名抗体阳性者在第3、6、9、12个月的抗体阳性率和GMT分别为100%和104.09;75.95%和58.33;64.56%和45.23;54.43%和41.82,差异有显著统计学意义(P<0.01)。无论性别或年龄,抗体阳性率和GMT均随时间推移显著降低(P<0.01)。结论甲型H1N1流感疫苗的血清抗体水平随时间推移快速下降,免疫力不持久。In order to investigate the rise and fall of serum HI antibody induced by 2009 influenza A（H1N1） vaccine to provide evidence for immunization strategy,serum specimen were collected from 128 vaccine recipients at the 3 rd,6 th,9 th and 12 th month after vaccination.Antibody titres were measured with haemagglutination inhibition（HI） assay.The positive rates in 128 recipients at the 3rd,6th,9th and 12th month were 61.7%,47.7%,40.9% and 35.43%,respectively;and the geometric mean titers（GMTs） of HI antibody were 40,28.4,24.5,and 23.6,respectively;both differences were significant（P0.01）.The positive rates and GMTs were significantly decreased with time in both male and female（P0.01）,and GMTs were significantly decreased in all age groups as well（P0.01）.For 79 subjects with positive HI antibody,the positive rates at the 3rd,6th,9th and 12th month were 100%,75.95%,64.56% and 54.43%;GMTs were 104.09,58.33,45.23 and 41.82,respectively;and the differences were significant（P0.01）.No matter gender or age,the positive rates and GMTs were significantly decreased with time（P0.01）.The data suggest that the levels of HI antibody induced by 2009 influenza A（H1N1） vaccine decline rapidly and the immunogenicity is not lasting.

关 键 词：甲型H1N1流感疫苗 血清HI抗体 免疫效果 抗体消长 

分 类 号：R373.1[医药卫生—病原生物学]