异槲皮苷-甲基-β-环糊精包合物的制备  

PREPARATION OF ISOQUERCITRIN-DIMETHYL-β-CYCLODEXTRIN INCLUSION COMPLEX

作　　者：李文超[1] 李晓秋[1] 王子娇[1] 刘俊勇[1] 董毅[1] 

机构地区：[1]牡丹江医学院药学院,黑龙江牡丹江157011

出　　处：《牡丹江医学院学报》2012年第3期4-6,共3页Journal of Mudanjiang Medical University

基　　金：牡丹江医学院大学生科研项目(2011-16)

摘　　要：目的:研究异槲皮苷-甲基-β-环糊精包合物的制备。方法:采用搅拌法制备异槲皮苷-甲基-β-环糊精包合物,利用红外光谱法和核磁共振法鉴定包合物的形成,并利用相溶解度法对其增溶效果进行研究。结果:通过红外光谱和核磁共振图谱对比分析显示异槲皮苷-甲基-β-环糊精包合物已形成;甲基-β-环糊精对异槲皮苷的增溶效果显著。结论:该制备方法合理、稳定可行且异槲皮苷经甲基-β-环糊精包合后,其溶解度得到显著提高。Objective： To prepare inclusion complex of isoquercitrin （IQ） with dimethyl -β- cyclodextrin （ ME - β- CD）. Meth- ods： IQ - ME - β- CD was prepared by stirring method and identified by Fourier transformation - infrared （FTIR） spectroscopy and 1H Nuclear magnetic resonance （ 1H - NMR） spectroscopy. Phase - solubility measurements were carried out to investigate the in- creasing of the water solubility of IQ. Results： It was demonstrated that inclusion complex of IQ with ME - β- CD was formed accord- ing to the analysis of FTIR spectrum and 1 H - NMR spectrum. It is found that the aqueous solubility of IQ was significantly increased by forming an inclusion complex with ME - β- CD. Conclusion： The preparation process above presented the most rational, conven- tional and stable method, and increased the preparation efficiency of IQ - ME -β-CD. The solubility and dissolution rate of IQ were evidently enhanced bv inclusion complex.

关 键 词：异槲皮苷 甲基-β-环糊精 包合物 相溶解度 

分 类 号：R9[医药卫生—药学]