D2-40在胸腺上皮肿瘤中的表达及临床意义  

Clinical significances of D2-40 expression in thymic epithelial tumors

作　　者：袁东风[1] 江华[1] 刘凡英[1] 

机构地区：[1]山东大学附属省立医院胸外科,济南250021

出　　处：《山东大学学报（医学版）》2012年第7期68-73,共6页Journal of Shandong University:Health Sciences

基　　金：山东省医药卫生科技发展计划(2009HZ058)

摘　　要：目的探讨D2-40在胸腺上皮肿瘤(TET)中的表达,分析D2-40表达与肿瘤侵袭和预后的关系。方法采用免疫组织化学染色法观察D2-40在160例胸腺上皮肿瘤和40例正常胸腺标本中的表达情况,术后连续随访5年以上。应用统计学软件分析D2-40表达与肿瘤侵袭和预后的关系。结果 D2-40在TET及正常胸腺中的阳性表达率分别为58.8%(94/160)和20%(8/40),差异有统计学意义(P=0.013)。D2-40在TET中的表达与TET侵袭性有关(P<0.01)。D2-40阳性表达组和阴性表达组患者5年生存率分别为32%、90%(P<0.01)。结论D2-40在TET中的表达高于正常胸腺组织,且随着侵袭性的增强,表达也增强。D2-40表达阳性的患者预后较差。Objective To investigate the expression of D2-40 in thymic epithelial tumors （TET） and its significance in tumor invasion and prognosis. Methods Immunohistochemical method was used to assess the expression of D2-40 in 160 samples of thymic epithelial tumors and 40 samples of normal thymuses. All cases were followed-up for more than 5 years after operation. Statistics softwares were used to analyze the correlation between the expression of D2-40 and the tumor invasion and prognosis. Results The positive rate of D2-40 expression in 160 TET and 40 normal thymuses were 58.8 % （94/160） and 20% （ 8/40 ） respectively, and the difference was statistically significant （ P = 0.013 ）. The expression of D2-40 in TET was correlated with the invasion of TET （P 〈0.01 ）. The 5-year-survival rates of the pa- tients in the D2-40 expression positive group and the negative group were 32% and 90% respectively （ P 〈 0.01 ）. Conclusion Expression of D2-40 is higher in the TET than in the normal thymus, which correlates with the aggression of TET. The patients with D2-40 positive expression have worse prognosis.

关 键 词：D2-40 胸腺上皮肿瘤 侵袭 预后 

分 类 号：R655.7[医药卫生—外科学]