HPLC法测盐酸左西替利嗪颗粒的含量  

Content detemination of levocetirizine granules by HPLC method

作　　者：洪江游 洪志慧[2] 凌日金 谢清春[3] 

机构地区：[1]海南康芝药业股份有限公司,570311 [2]深圳市红会医院 [3]广东药学院

出　　处：《中国现代药物应用》2012年第13期4-5,共2页Chinese Journal of Modern Drug Application

摘　　要：目的建立盐酸左西替利嗪颗粒含量的高效液相色谱测定法。方法采用C18柱,以甲醇-磷酸二氢钠溶液(70∶30)为流动相,流速1ml/min,检测波长230nm。结果在4.98～49.8μg/ml范围内呈线性关系,进样精密度、重复性试验和中间精密度的RSD分别为0.25%、0.49%和0.61%,低中高三个浓度的回收率分别是99.41%、99.55%和99.64%。结论本法可用于盐酸左西替利嗪颗粒含量测定。Objective To establish a HPLC method to determine the content of levocetirizine granules. Methods C18 column was used, menthol alcohol-Sodium dihydrogen phosphate （70： 30） as mobile phase, flow rate at 1 ml/min, detection wavelength at 230nm. Results In 4. 98 - 49.8 μg/ml was line. Instrument precision, Repeatability test, middle precision was 0.25 %, 0. 49% and 0. 61% respectively. Recoveries （low level, middle level, and high level） were 99. 41%, 99. 55% and 99. 64% respectively. Conclusion The assay method can be used to determine content of levocetirizine granules.

关 键 词：盐酸左西替利嗪 HPLC 含量测定 

分 类 号：R927.2[医药卫生—药学]