间甲氧基苯酚的合成工艺研究  

Study of Synthesis of m-Methoxyphenol

作　　者：韩莹[1,2] 傅东林[1] 姚勇[1] 邹丽娜[1] 颜朝国[1] 

机构地区：[1]扬州大学化学化工学院,江苏扬州225002 [2]南京大学化学化工学院,江苏南京210093

出　　处：《化工时刊》2012年第6期1-2,7,共3页Chemical Industry Times

基　　金：国家自然科学基金(No.21172190)项目资助;江苏高校优势学科建设工程项目资助

摘　　要：以间苯二酚和硫酸二甲酯为原料,用相转移催化法合成间甲氧基苯酚。运用正交设计法,重点考察相转移催化剂种类、原料配料比、反应温度和反应时间等因素对收率的影响,确定的最佳工艺条件:以四丁基溴化铵为相转移催化剂,配料比为1∶1.2,温度为80℃,反应时间为8 h,收率达到66%。m - Methoxyphenol was prepared in toluene/H20 solution in the presence of phase transfer catalyst by resorcinol and dimethyl sulfate as raw materials. The influence on the rate of production of m - methoxyphenol a- bout different of catalyst, ratio of mole, react temperature and react time was discussed by using orthogonal design. The optimum reaction conditions were specified as follows ： TBAB as catalyst, mole ratio of 1 ： 1.2, the reaction tem- perature was 80 ℃ and the reaction time was 8 hours. The yield reached 66%.

关 键 词：间甲氧基苯酚 硫酸二甲酯 相转移催化 正交设计 

分 类 号：TQ243.12[化学工程—有机化工]