当归藤水提物和醇提物急性毒性实验研究  

Experimental study of acute toxicity of water extract and ethanol extract of Angelica vine

作　　者：卢森华[1] 陈勇[1] 曾海生[1] 张龙[1] 郑锡任[1] 周媛[1] 

机构地区：[1]广西中医学院药学院,广西南宁530001

出　　处：《中国医药导报》2012年第19期29-30,共2页China Medical Herald

基　　金：广西自然科学基金--创新研究团队项目(项目名称:中药新药基础研究;项目编号:2011GXNSFF018006);2011年度广西壮族自治区中医药管理局中医药民族医药自筹经费科研课题(项目编号:gz-zc1120)

摘　　要：目的对当归藤水提取物和醇提取物的急性毒性进行初步研究,评价其安全性,为新药开发提供理论依据。方法采用最大给药量测定法,小鼠灌胃给药测定当归藤水提取物和醇提物的半数致死量(median lethal dose,LD50)或最大耐受量(maximum tolerated dose,MTD),研究其安全性。结果当归藤水提取物和醇提取物的毒性都很小,未测得灌胃给药小鼠半数致死量LD50,水提取物和醇提取物的MTD>90 g/kg,最大耐受量倍数相当成人(50 kg)用量的150倍。结论当归藤无明显毒性,临床常用量安全可行。Objective To study the acute toxicity of water extract and ethanol extract of Angelica vine, evaluate their safety and provide theoretical basis for the development of new drugs. Methods The maximum administration determination method was used and the drug was administered orally. The median lethal dose （LD50） and maximum tolerated dose （MTD） of water extract and ethanol extract of Angelica vine were measured to study the safety. Results The toxicity of water extract and alcohol extract of Angelica vine was very small, thus the LD50 of mice could not be obtained. MTD of water extract and ethanol extract was larger than 90 g/kg. The maximum tolerated dose multiple equals 150 times of the dose for adults （50 kg）. Conclusion Angelica vine does not have apparent toxicity, thus its clinical routine dose is safe and feasible.

关 键 词：当归藤 急性毒性实验 最大耐受量 

分 类 号：R284.1[医药卫生—中药学]