体外循环心内直视手术中大剂量国产抑肽酶的止血作用及机制(附120例临床分析)  

Reduction of Postoperative Bleeding After Cardiopulmonary Bypass By High-dose Aprotinin 120 clinical analysis

作　　者：何忠良[1] 张赛[1] 张昌铭[1] 朱家光[1] 徐世伟[1] 陈芳[1] 

机构地区：[1]浙江大学医学院附属第二医院心胸外科,310009

出　　处：《浙江临床医学》2000年第2期78-79,80,共3页Zhejiang Clinical Medical Journal

摘　　要：探讨体外循环中大剂量国产抑肽酶的止血作用及机制。方法：１２０例体外循环心内直视手术病人随机分为抑肽酶组和对照组。实验组抑肽酶剂量６万ＫＩＵ／ｋｇ。选点测定血中ＰＣ、Ｆｉｂ、ＦＤＰ等指标的变化并观察术中术后的出血量和输血量。结果：用药组出血量和输血量分别比对照减少５０％左右。ＦＤＰ较对照组降低（Ｐ＜０．０５）。Ｆｉｂ较对照组增高（Ｐ＜０．０５）。结论：大剂量国产抑肽酶有明显的止血效果，抑制纤溶是止血的机制之一。To observe the reduction of postoperative bleeding after cardiopulmonary bypass(CPB) by high - dose aprotinin or placebo(control coup). Concentration of fibrin degradation products (FDP), fibrin(Fib) and platelet(PC) was analized as well as the amount of postoperative bleeding and transfu- sion. Results: the aprotinin group showed a significent reduction of postpetative bleeding and transfusion, lower con- cetration of FDP and higher of Fib. PC was not statitically different. Conclusion: high - dose aprotinin significently reduce postoperative bleeding in a possible way of fibrolysis inhibiion.

关 键 词：抑肽酶 体外循环 止血 抑制纤溶 心内直视手术 

分 类 号：R654.2[医药卫生—外科学]