晚期血吸虫病巨脾型患者肝脏胶原与血清肝纤维化指标的相关性研究  

The Relation between the Liver Collagen Immunohistochemical and Serum Liver Fibrosis Indexes with Advanced Schistosomiasis Japonica with Splenomegaly

作　　者：陈盛铎[1] 罗仁寿 雷勋杰 杨培明[1] 张振鄂[1] 

机构地区：[1]湖北中医学院附属医院,武汉430061 [2]湖北省潜江市血防所 [3]湖北省公安县血防所

出　　处：《中西医结合肝病杂志》2000年第1期9-11,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：湖北省委血防办公室资助

摘　　要：目的:探讨晚期血吸虫病巨脾型患者肝脏胶原与血清肝纤维化指标之间的关系。方法:采用免疫组化LSAB法,计算机图像分析和放射免疫法测定晚期血吸虫病巨脾型患者肝脏Ⅰ、Ⅲ、Ⅳ型胶原量燕计算Ⅰ/Ⅲ型胶原比值,同步检测血清PCⅢ、HA和CⅣ量。结果:血清HA与肝脏Ⅰ型胶原量,PCⅢ和CⅣ与Ⅰ/Ⅲ型胶原比值显著正相关。结论:血清PCⅢ和CⅣ能反映肝纤维化程度,血清肝纤维化指标与肝脏胶原病理检查对诊断肝纤维化具有互补性。Aim: To explore the relation between the levels of liver collagen and serum liver fibrosis indexes in patients with abvanced schistosomiasis japanica with splenomegaly (ASJS). Methods: The liver collogens type Ⅰ.Ⅲ and Ⅳ were stained with immunohistochemical LSAB technique and were quantified with computer imaging analysis system with ASJS. Meanwhile, the rate of liver collagen type Ⅰ/Ⅲ was calculated and the serum PCⅡ HA and C Ⅳ were tested with RIA technique. Results: There was significant correlation between the serum HA and the liver collagen type Ⅰ,the serum PC Ⅲ , CⅣ and the rate of liver collagen type Ⅰ/Ⅲ.Conclusion : The serum PC Ⅲ and C Ⅳcould reflect the degree of liver fibrosis, Testing the serum liver fibrosis indexes and liver collagen pathologic indexes to diagnose the liver fibrosis could complement each other.

关 键 词：血吸虫病 肝纤维化 免疫组化 计算机图象分析 

分 类 号：R532.2[医药卫生—内科学]