α-常春藤皂苷丙烯酸树脂L100纳米粒的制备及其体外评价  

Preparation and in vitro evaluation of Saponins PD-loaded Eudragit L100 nanoparticles

作　　者：耿丽娟[1] 游本刚[1] 唐丽华[1] 朱蓉[1] 

机构地区：[1]苏州大学医学部药学院,江苏苏州215123

出　　处：《苏州大学学报（医学版）》2012年第3期363-368,共6页Suzhou University Journal of Medical Science

基　　金：国家自然科学基金青年基金资助项目(81102818)

摘　　要：目的制备和评价α-常春藤皂苷-丙烯酸树脂Eudragit L100纳米粒(SPD-L100-NPs)。方法采用改良乳化-溶剂扩散法制备纳米粒,以粒径大小、包封率(EE)和多分散指数(PI)为指标,通过单因素试验和正交试验设计优化制备工艺。通过红外光谱、X射线衍射、差示扫描量热分析、体外释放试验等对纳米粒的相关性质进行评价。结果所制备的纳米粒外观圆整,平均粒径为(65.2±1.6)nm,EE为(99.13±0.20)%,PI值为0.384±0.008。药物在纳米粒中均被载体材料有效包裹,其体外释放具有显著的pH依赖性。结论采用改良乳化-溶剂扩散法可制备出包封率高、大小均匀的pH依赖性纳米粒。Objective To prepare and evaluate Saponins PD loaded Eudragit L100 nanoparticles （SPD-L100-NPs）. Methods The SPD-L100-NPs were prepared by modified quasiemulsion solvent dif- fusion technique. Taking particle size, entrapment efficiency （EE） and polydisperse index （PI） as com- prehensive indexes, the orthogonal test design was used to optimize the preparation process. Fourier trans- form infrared spectrometer（ FT-IR）, differential scanning calorimetry（DSC） and X-ray diffraction（XRD） were applied to evaluate nanoparticle; and in vitro release was investigated. Results Novel nanoparticles were spherical, average in particle size （65.2±1.6） nm, EE （99.13±0.20） % , PI （0. 384±0. 008 ）. The release of SPD significantly depended on the pH conditions. Conclusion SPD-L100-NPs have high EE and homogeneous size distribution. The effect of drug sustained release of nanoparticles is significant.

关 键 词：α-常春藤皂苷 丙烯酸树脂L100 纳米粒 释放 

分 类 号：R944[医药卫生—药剂学]