血小板相关抗体、巨核细胞数量对免疫性与非免疫性血小板减少患者的诊断意义  

Diagnostic significance of platelet-associated Ig and the number of megakakaryocytes in immune and non-immune thrombocytopenia

作　　者：陈立[1] 秦晓铧[1] 谢晓玲[1] 陈国枢[1] 

机构地区：[1]广东省惠州市中心人民医院血液科,广东惠州516001

出　　处：《中国医药科学》2012年第11期96-97,105,共3页China Medicine And Pharmacy

摘　　要：目的比较骨髓巨核细胞数量、血小板相关抗体在免疫性血小板减少和非免疫性血小板减少患者中的不同,探讨巨核细胞数量、血小板相关抗体在血小板减少症诊断中的意义。方法观察132例ITP患者及48例非ITP患者的骨髓巨核细胞数量、血小板相关抗体水平,进行统计分析。结果 132例ITP患者中巨核细胞数量正常者35例,增多者78例,77例ITP患者中血小板抗体阳性58例。结论由于血小板抗体生成使ITP患者巨核细胞成熟障碍,因此血小板生成减少,骨髓巨核细胞数量在免疫性血小板减少的诊断中是必要的检查,血小板抗体与巨核细胞数量相关。Objective To compare the number of bone marrow megakaryocyte and plateletet-associated Ig in immune thrombocytopenia and non ITP patients.To discuss the diagnostic significance of the number of megakaryocyte and plateletet- associated Ig in immune thrombocytopenia and non ITP patients. Methods Observe bone marrow megakaryocyte counts and plateletet-associated antibody in 132 cases with immune thrombocytopenia and 48 cases with non ITP. And datas were analyzed. Results 35 cases＇s megakaryocyte number was normal,78 cases＇s megakaryocyte number was increased of 132 cases with ITP. Plateletet-associated Ig of 58 cases was positive in 77 cases with ITP. Conclusion As the formation of plateletet-associated Ig result in megakaryocyte maturation disorders of patients with ITP. Bone marrow megakaryocyte counts in the diagnosis of immune thrombocytopenia is a necessary examination.

关 键 词：免疫性血小板减少紫癜 血小板相关抗体 巨核细胞数量 

分 类 号：R554.6[医药卫生—血液循环系统疾病]