Modern quantitative genetics:Dissecting complex polygenic systems into individual genetic factors  

作　　者：WU WeiRen 

机构地区：[1]College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China

出　　处：《Chinese Science Bulletin》2012年第21期2635-2636,共2页

摘　　要：Modern quantitative genetics began in the late 1980s with the advent and application of molecular marker technology.Molecular markers made it possible to genotype the entire genome of an individual.Thus,for the first time,quantitative genetic analysis could be performed based on phenotypic and genotypic information.As a result,quantitative genetic studies were no longer limited to the estimation of genetic parameters by treating the polygenic system as a whole,but were able to identify the locations and effects of individual quantitative trait loci (QTLs) as well as to examine the interactions between QTLs.Modem quantitative genetics began in the late 1980s with the advent and application of molecular marker technology. Mo- lecular markers made it possible to genotype the entire genome of an individual. Thus, for the first time, quantitative genetic analysis could be performed based on phenotypic and genotypic information. As a result, quantitative genetic studies were no longer limited to the estimation of genetic parameters by treating the polygenic system as a whole, but were able to identify the locations and effects of individual quantitative trait loci （QTLs） as well as to examine the interactions between QTLs. Since the early 1990s, molecular marker technology has developed very rapidly. In particular, during the last decade, high-throughput genomic approaches such as microarray and next generation sequencing have been developed, making pos- sible the simultaneous detection of tens or hundreds of thousands of polymorphic loci. These approaches have greatly en- hanced the efficiency of molecular marker analysis, making genome genotyping easier and no longer a bottleneck in genetic studies. The fast progress of molecular marker technology has significantly advanced the development of modem quantitative ~enetics, making it one of the hottest research areas in life sciences.

关 键 词：数量遗传学 基因组学 遗传因素 个体 系统 分子标记技术 解剖 数量遗传分析 

分 类 号：Q348[生物学—遗传学] Q78