Associations between gene polymorphisms in two crucial metabolic pathways and growth traits in pigs  

作　　者：YANG Fan WANG QiongPing WANG MingHui HE Kan PAN YuChun 

机构地区：[1]School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China [2]Shanghai Key Laboratory of Veterinary Biotechnology,Shanghai 200240,China

出　　处：《Chinese Science Bulletin》2012年第21期2733-2740,共8页

基　　金：supported by the National Natural Science Foundation of China(31072003,31000992,and30871782);National High Technology Research and Development Program of China(2008AA101009and2006AA10Z1E3);the National Key Basic Research Program of China(2006CB102102)

摘　　要：Propanoate metabolism and fatty acid metabolism are crucial metabolic pathways in vivo that have been studied extensively and have shown a significant influence on the growth and diseases of animals.In order to identify the essential genes significantly associated with porcine growth traits at the pathway level,we selected 14 candidate genes with 58 SNPs,including 24 tag SNPs and 34 predicted SNPs,in the two essential pathways to test using the SNaPshot mini-sequencing method.Association analysis was performed using both static and dynamic phenotypic records.The results showed that four SNPs,respectively in SUCLA2,SUCLG2,ACADS,and ALDH1B1,were significantly associated with growth in pigs.In addition,an exciting finding was that the change of transcription factor binding site that resulted from alteration of the bases in SUCLG2 brought out a transcription factor binding site for POU1F1a,which is the product of a notable marker gene for growth of animals.Propanoate metabolism and fatty acid metabolism are crucial metabolic pathways in vivo that have been studied extensively and have shown a significant influence on the growth and diseases of animals.In order to identify the essential genes significantly associated with porcine growth traits at the pathway level,we selected 14 candidate genes with 58 SNPs,including 24 tag SNPs and 34 predicted SNPs,in the two essential pathways to test using the SNaPshot mini-sequencing method.Association analysis was performed using both static and dynamic phenotypic records.The results showed that four SNPs,respectively in SUCLA2,SUCLG2,ACADS,and ALDH1B1,were significantly associated with growth in pigs.In addition,an exciting finding was that the change of transcription factor binding site that resulted from alteration of the bases in SUCLG2 brought out a transcription factor binding site for POU1F1a,which is the product of a notable marker gene for growth of animals.

关 键 词：生长性状 基因多态性 代谢途径 关联分析 转录因子结合位点 单核苷酸多态性 猪 SNPS 

分 类 号：S828[农业科学—畜牧学]