针刺对功能性便秘ENS-ICC调节机制的研究进展  

Progress in understanding mechanisms underlying the regulatory effect of acupuncture on functional constipation

作　　者：任驰[1] 周思远[1] 牟建蛟[1] 李瑛[1] 

机构地区：[1]成都中医药大学针灸推拿学院,四川省成都市610075

出　　处：《世界华人消化杂志》2012年第19期1758-1762,共5页World Chinese Journal of Digestology

基　　金：国家重点基础研究发展计划(973计划)基金资助项目;No.2011CB505205;四川省科技厅基金资助项目;No.2012jY0039~~

摘　　要：功能性便秘(functional constipation,FC)是临床常见病和多发病,其病因和发病机制尚不十分清楚,存在多种学说.实验研究表明,"泻药性结肠"动物模型结肠表现为肠神经系统神经丛超微结构、多种受体与ICC表达的异常.我们通过检索和分析近年来针刺治疗FC的实验研究文献,发现目前针刺对FC的调节机制的研究偏于单一化,多种机制之间的调控关系没有进行深入研究.今后的研究应侧重针刺对各机制之间相互关系的阐释以及对其关键机制的探讨,使针刺作用机制的研究进一步深入,从而更好地服务于临床.Functional constipation is a common and fre- quently-occurring disease whose etiology and pathogenesis are still not very clear. Experimental studies using animal models of cathartic colon have shown abnormalities in ultrastructural plexus of enteric nervous system （ENS）, expres- sion of multiple receptors, and interstitial cells of Cajal （ICC）. Currently, there has been no consen- sus reached yet with regard to the mechanisms underlying the regulatory effect of acupuncture therapy on functional constipation, and the inter- action among different regulatory mechanisms is not examined in depth. Future research should address this issue,to better understand how acu- puncture exerts therapeutic effects against func- tional constipation.

关 键 词：功能性便秘 肠神经系统 CAJAL间质细胞 

分 类 号：R245[医药卫生—针灸推拿学]