妊娠妇女抗心磷脂抗体的调查及其与不良妊娠的关系  

Investigation of Anticardiolipin in Pregnant Women and Its Relationship with Abnormal Pregnancy

作　　者：卢洁[1] 张德亭[1] 戴利亚[1] 

机构地区：[1]温州市第三人民医院,325000

出　　处：《医学研究杂志》2012年第6期158-160,共3页Journal of Medical Research

摘　　要：目的通过检测抗心磷脂抗体(aCL)水平,调查温州地区妊娠妇女aCL的阳性率及亚型的分布。方法应用酶联免疫吸附法(ELISA)技术检测妊娠孕妇aCL水平,分析其与不良妊娠的关系。结果 3448例妊娠待产孕妇中aCL阳性者79例,阳性率2.3%;79例aCL阳性孕妇其亚型以IgG和IgM多见,发生不良妊娠亦以IgG和IgM亚型多见;79例aCL阳性孕妇其抗体效价以低效价为主(73.4%),中效价次之(25.3%),高效价仅出现1例(1.3%);aCL阳性与阴性的孕妇的妊娠结局比较,其各种不良妊娠的发生率均没有统计学意义(P均>0.05)。结论 aCL在温州地区妊娠妇女中阳性率较低,对妊娠结局影响不大,可能不是孕妇不良妊娠的危险因素。Objective To investigate the positive rate and subtype＇s distribution of anticardiolipin（aCL） by its level. Methods The levels of anticardiolipin from pregnant women were tested by technique of ELISA, and the relationship with abnormal pregnancy was analyzed as well. Results There was positive rate of 2.3% in 3448 cases of pregnant women with common subtypes of IgG and IgM which mainly were low titre（73.4% ）. No statistical significance occurred between aCL and abnormal pregnancy（P 〉 O. 05）. Conclusion aCL may be not the risk factor of abnormal pregnancy for its low positive rate happening in Wenzhou region.

关 键 词：抗心磷脂抗体(aCL) β2-糖蛋白1妊娠结局不良妊娠流产 

分 类 号：R714.21[医药卫生—妇产科学]