左旋氨氯地平合用辛伐他汀对高血压患者血压及左室肥厚的影响  

Effects of levo-amlodipine and simvastatin on blood pressure and left ventricular hypertrophy in hypertensive patients

作　　者：景胜[1] 杨国君[1] 麦一峰[1] 周忠[1] 刘丽红[1] 

机构地区：[1]宁波大学医学院附属医院,宁波315020

出　　处：《现代实用医学》2012年第5期496-498,共3页Modern Practical Medicine

基　　金：浙江省医学会临床科研基金项目(NO2007ZYC41)

摘　　要：目的观察辛伐他汀对高血压患者血压及左室重量指数的影响。方法将156例高血压患者分为对照组(=82)和实验组(=74)。对照组治疗为左旋氨氯地平片2.5 mg/d,若2周不能使血压达标,则可加量至5 mg/d,若仍不能达标,可加利尿剂或其他降压药。实验组在对照组基础上,另加用辛伐他汀20 mg晚上用药1次,观察期为12个月。观察两组治疗前后血压变化,并分别在用药前、用药后12个月应用超声心动图检查评价心肌肥厚程度。结果两组治疗前血压、血脂、心脏彩色多普勒超声检查各参数差异均无统计学意义(均>0.05);治疗12个月后,实验组收缩压、舒张压、舒张期间隔厚度、舒张期左室后壁厚度和左室重量指数均较对照组低(均<0.05)。结论左旋氨氯地平合用辛伐他汀对原发性高血压左室肥厚逆转有协同作用,较单一用药疗效显著。Objective To observe the effects of simvastatin on blood pressure and left ventricular mass index（LVMI ）in hypertensive patients. Methods One hundred and fifty-six hypertensive patients, receiving levo-amlodipine （2.5mg/d） as basic antihypertensive regimen, were randomly divided into the experimental group and the control gro- up. And simvastatin （20rag/d） was added to the experimental group. Blood pressure before and after treatment was observed; myocardial hypertrophy degree was assessed by ultrasound echocardiography before and 12-month after treatment. Results Before treatment, there were no differences on blood pressure, blood lipids, parameters of color Doppler ultrasound （P 〉 0.05）. After 12 months, significant reductions of systolic blood pressure and diastolic blood pressure were observed in the experimental group as compared with those in the control group （P 〈 0.05）. In the meanwhile, IVST, LVPW and LVMI were significantly decreased inthe experimental group （P 〈 0.05）.Conclusions Lamlodipine combined with simvastatin have synergistic effects on reducing blood pressure and reversal of left ventricular hypertrophy of essential hypertension, which are more significant than those of the single antihypertensive regimen.

关 键 词：高血压 左旋氨氯地平 辛伐他汀 左室重量指数 

分 类 号：R544.1[医药卫生—心血管疾病]