重楼皂苷类化合物对小鼠腹腔巨噬细胞吞噬功能的影响  

The Effects of the Saponins in Rhizoma Paridis Yunnanensis on Phagocytic Function of Peritoneal Macrophages of Mice

作　　者：杨黎江[1] 沈放[1] 王德斌[2] 路斌[1] 马银海[3] 

机构地区：[1]昆明学院生命科学与技术系,云南昆明650214 [2]昆明学院农学院,云南昆明650214 [3]昆明学院化学科学与技术系,云南昆明650214

出　　处：《昆明学院学报》2012年第3期30-32,共3页Journal of Kunming University

基　　金：云南省教育厅科学研究基金资助项目(09C0132)

摘　　要：将重楼皂苷类化合物PHAC-A和PHAC-B配制为高、低质量浓度组,以灌胃方式连续给药7 d,测定小鼠腹腔巨噬细胞的吞噬百分率和吞噬指数.结果显示,PHAC-A,PHAC-B高、低质量浓度组对小鼠腹腔巨噬细胞吞噬百分率和吞噬指数的影响均高于对照组和阳性对照组(P<0.05);两组比较,PHAC-A对巨噬细胞吞噬功能的促进作用明显高于PHAC-B.结果表明,重楼皂苷类化合物对小鼠腹腔巨噬细胞吞噬功能具有明显促进作用,并以PHAC-A的作用最强.Mice were administered intragastrically different dose of the Saponins in Rhizoma Paridis Yunnanensis,PHAC-A or PHAC-B,for 7 continuous days,then the devouring percentage and index of peritoneal macrophage cells were determined.The results show that both the high and the low dose of PHAC-A or PHAC-B develop the devouring percentage and index of peritoneal macrophage cells,which is significantly higher than that of the negative group and the positive group（P〈0.05）.Compared to PHAC-B,PHAC-A has better effect on the macrophage phagocytosis.The results suggest that the Saponins in Rhizoma Paridis Yunnanensis,especially PHAC-A,can obviously develop phagocytic function of peritoneal macrophages.

关 键 词：重楼 偏诺皂苷 薯蓣皂苷 巨噬细胞 吞噬作用 

分 类 号：R285[医药卫生—中药学]