趋化因子及其受体在干燥综合征中的作用  

Chemokines and Its Receptors in Sjogren's Syndrome

作　　者：金莉[1] 厉小梅[1] 

机构地区：[1]安徽医科大学附属省立医院风湿免疫科,合肥230001

出　　处：《中华临床免疫和变态反应杂志》2012年第2期131-135,共5页Chinese Journal of Allergy & Clinical Immunology

基　　金：国家自然科学基金(30872340);安徽省高层次人才创新创业资金(090413129)

摘　　要：干燥综合征(SS)是一种慢性系统性自身免疫性疾病,其典型病理表现为外分泌腺导管周围CD4+T淋巴细胞、B淋巴细胞、树突状细胞、巨噬细胞浸润以及异位生发中心的形成。趋化因子(chemokines)及其受体在SS炎性细胞迁移至病灶腺体及促进异位生发中心的形成过程中起着重要作用。本文就趋化因子及其受体的来源和生物学特征以及与SS关系的新近研究进展,进行较为系统的综述。Sjogren’s syndrome（SS）is a chronic systemic autoimmune disease,and it is characterized histologically by peri-ductal aggregation of CD4 T lymphocytes,B lymphocytes,dendritic cells,macrophages and the formation of ectopic germinal centers.It has been suggested that chemokines and its receptors control the selective traffic and tissue homing of inflammatory cells,promote the formation of ectopic germinal centers.This reviewe will examine the source and biological characteristics of chemokines and its receptors as well as the new insight into its relationship with SS.

关 键 词：趋化因子 趋化因子受体 干燥综合征 

分 类 号：R593.2[医药卫生—内科学]