草果挥发油对罗通定贴剂的经皮促渗作用  

Enhancing Effect of Volatile Oil from Amomum tsaoko on Percutaneous Penetration of Rotundine Patch

作　　者：黄金娥[1] 马云淑[1] 张贵华[1] 罗红梅[1] 

机构地区：[1]云南中医学院中药学院,昆明650500

出　　处：《中国实验方剂学杂志》2012年第13期7-10,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30960517)

摘　　要：目的:考察草果挥发油对罗通定贴剂经皮渗透作用的影响。方法:采用改良Franz扩散池进行小鼠体外经皮渗透试验。HPLC测定罗通定累计渗透量,考察不同质量分数草果挥发油对贴剂中罗通定的促渗作用。结果:质量分数5%,7%,10%的草果挥发油对贴剂中罗通定有一定促渗作用,罗通定12 h累计渗透量依次为3.848,4.329,4.914 mg.cm-2,增渗倍数分别为1.014,1.127,1.282倍。结论:草果油可促进贴剂中罗通定的渗透作用。在一定范围内,随其质量浓度的增大促渗作用增强。Objective： To study on effect of volatile oil from Amomum tsaoko on percutaneous penetration of Rotundine patch. Method： In vitro percutaneous penetration test in rat was conducted by using a modified Franz diffusion cell. Accumulative penetration volume of rotundine was determined by HPLC, enhancing effect of different concentrations of volatile oil from A. tsaoko on percutaneous permeation of rotundine in the patch was investigated. Result： The concentration of 5%, 7% and 10% of volatile oil from A. tsaoko had a certain enhancing effect on permeation of rotundine in the patch, average cumulative penetration volume of rotundine in 12 h of 5% , 7% , 10% volatile oil were 3. 848, 4. 329, 4. 914 mg ·cm^-2, multiples of enhancing permeation in 12 hours were 1. 014, 1. 127, 1. 282. Conclusion： Volatile oil from A. tsaoko could enhance percutaneous penetration of rotundine in the patch. With a certain range, percutaneous penetration was enhancing with increasing the concentration of volatile oil from A. tsaoko.

关 键 词：罗通定 草果 挥发油 经皮渗透 

分 类 号：R283.6[医药卫生—中药学]