不同制备技术对新健胃片中黄芩苷稳定性的影响  

Influence of Stability for Baicalin in Xinjianwei Tablet by Different Preparation Techniques

作　　者：杨冬丽 郑艳春 黄飞龙 刘井利 牛向伟 

机构地区：[1]承德颈复康药业集团有限公司,河北省中药新辅料工程技术研究中心,河北承德067000

出　　处：《中国实验方剂学杂志》2012年第13期50-53,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:考察不同制备技术对新健胃片中黄芩苷稳定性的影响。方法:采用恒温加速试验考察粉末包衣、固体分散及包芯片技术对提高黄芩苷稳定性的影响。结果:固体分散及包芯片技术制备的样品均能使新健胃片中黄芩苷保持稳定。结论:固体分散、包芯片技术的应用可解决新健胃片中黄芩苷的稳定性问题。其中应用包芯片技术制备样品,辅料用量较少,操作简便,更易产业化。Objective： To investigate influence of different preparation techniques on stability of baicalinin from Xinjianwei tablet. Method： Influence of powder coating, solid dispersion and package chip technology to improve stability of baicalin was investigated by thermostatic accelerated test. Result： Prepared samples of solid dispersion and package chip technology could remain stable of baicalinfrom Xinjianwei tablet. Conclusion ： Solid dispersion and package chip technology could solve stability problem of baicalin from Xinjianwei tablet. Comparatively, package chip technology had many advantages, such as fewer amounts of excipients, more convenient operation and easier to industrialization.

关 键 词：新健胃片 黄芩苷 稳定性 粉末包衣 固体分散 包芯片 

分 类 号：R283.6[医药卫生—中药学]