不同工艺决明子配方颗粒与传统饮片的药效学比较  

Pharmacological Comparative Study between Different Prescription Granules and Decoction of Semen Cassiae

作　　者：陈艳芬[1] 刘伟民[2] 江滨[2] 曾元儿[2] 杨超燕[1] 邝武锋[1] 

机构地区：[1]广东药学院中药学院,广州510006 [2]广州中医药大学中药学院,广州510405

出　　处：《中国实验方剂学杂志》2012年第13期161-164,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划项目(2006BAI06A14-06)

摘　　要：目的:比较研究不同干燥工艺(喷雾、冷冻、真空)所制的决明子配方颗粒与传统饮片水煎剂的药效,为临床应用提供理论依据。方法:实验分别设正常组、模型组、阳性对照组、决明子饮片水煎组和配方颗粒的喷雾组、冷冻组、真空组,从正常小鼠小肠推进、燥结便秘小鼠排便、高血脂小鼠血清血脂水平[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)]3个方面考察相同剂量的决明子配方颗粒剂与水煎剂的药效差异。结果:3种配方颗粒均能显著促进正常小鼠小肠运动(P<0.01),但与水煎剂比较差异不明显;3种颗粒均能明显促进便秘小鼠排便,喷雾组、冷冻组的第一次排黑便时间与水煎组比较明显缩短(P<0.01和P<0.05);与高血脂模型组比较,喷雾组和冷冻组的血清TC,LDL-C明显降低(P<0.05),HDL-C明显升高(P<0.05),冷冻组的TG也明显降低(P<0.05),真空组和水煎组仅能降低TC(P<0.05)。结论:决明子配方颗粒总体药效优于同剂量的传统水煎剂,以冷冻颗粒和喷雾颗粒为佳。Objective： To compare the effects of three different prescription granules of Semen Cassiae prepared by spraying, freezing and vacuum process methods and traditional decoction, and to provide theoretical basis for clinical application. Method： The mice were divided into normal group, model group, positive control group, Semen Cassiae decoction group and spray group, frozen group, vacuum group of granules. The actions on intestinal propulsion in normal mice, defecation of dry constipation in constipation mice, and blood lipids inhyperlipidemia mice （including TC, TG, HDL-C, LDL-C） were observed to find the pharmacological differences at same dose. Result： Three granules significantly promoted intestinal movement in normal mice （P 〈 0. 01 ） ; but showed not evident difference compared with the decoction. Three granules groups promoted bowel movement in constipation mice, the first black fecal discharge time in spraying group and freezing group shortened evidently compared with the decoction （P 〈0. 01 and P 〈0.05）. Compared with hyperlipidemia model group, TC and LDL- C in spraying and freezing groups reduced （P 〈 0.05 ） , but HDL-C increased evidently （P 〈 0.05 ）, TG levels in freezing group also reduced evidently （P 〈 0.05）, the vacuum and decoction groups dnly showed significant differences in TC level （ P 〈 0.05）. Conclusion ： Semen Cassiae granules are superior to the traditional decoction in efficacy, especially freezing and spraying granules indicate more significant effects.

关 键 词：决明子 配方颗粒 水煎剂 泻下 调脂 

分 类 号：R285.5[医药卫生—中药学]