醒脑静联合还原型谷胱苷肽治疗肝性脑病  

Effects of Xingnaojing Injection Combined with Reduced Glutathione in the Treatment of Hepatic Encephalopathy

作　　者：陈蓉[1] 

机构地区：[1]安顺市人民医院感染性病科,贵州安顺561000

出　　处：《中国实验方剂学杂志》2012年第13期273-275,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察醒脑静注射液联合还原型谷胱甘肽治疗肝性脑病的临床疗效。方法:将符合病例入选标准的80例肝性脑病患者随机分为观察组、对照组各40例。两组患者均于入院后常规给予限制蛋白摄入、去除诱因、补充白蛋白、维持电解质紊乱等对症治疗。观察组同时给予醒脑静注射液20 mL+250 mL 5%葡萄糖注射液,gtt,1次/d;还原型谷胱甘肽0.6 g+250 mL生理盐水igtt,1次/d。两组均10 d为1个疗程,治疗2个疗程后评价疗效。结果:显效率观察组62.50%,对照组45.00%,两组差异显著(P<0.05)。总有效观察组95.00%,对照组80.00%,两组差异显著(P<0.05)。与治疗前比较,两组门冬酸氨氨基转移酶(AST),丙氨酸氨基转移酶(ALT),总胆红素(TBil),血氨水平显著下降(P<0.05),治疗后AST,ALT,TBil,血氨水平观察组分别为(143.93±75.41),(124.45±74.43)U.L-1,(155.92±71.21),(131.43±49.16)μmol·L-1,对照组分别为(113.75±70.58),(94.32±42.64)U.L-1,(117.31±61.23),(91.33±39.15)μmol·L-1,观察组改善强于对照组(P<0.05)。观察组发热、惊厥、意识障碍、脑膜刺激征、颅神经受累消失时间为(1.4±0.4),(0.9±0.4),(1.6±0.4),(1.7±0.6),(1.2±0.4)d,对照组为(4.5±2.5),(4.2±1.3),(5.2±0.6),(4.1±0.8),(3.8±0.4)d。观察组脑电图、脑脊液恢复正常时间、平均住院时间为(10.1±0.8),(6.1±0.6),(8.3±2.5)d,对照组为(12.2±1.8),(7.5±1.8),(14.2±2.9)d,均治疗组短于对照组(P<0.05)。结论:采用醒脑静联合还原型谷胱甘肽治疗肝性脑病临床疗效显著。Objective： To observe the effect of Xingnaojing injection combined with reduced glutathione in the treatment of hepatic encephalopathy. Method： Eighty cases of hepatic eneephalopathy were randomly divided into the observation group and the control group, 40 cases in each group. Two groups of patients after admission were given constraints on protein intake, removed incentives, supplement of albumin, maintained the electrolyte disorders such as symptomatic treatment. The observation group while giving the effect of Xingnaojing injection in 20 mL ＋ 250 mL 5% glucose injection, intravenous drip, 1 times a day; also the prototype of valley reduced glutathione 0.6 g ＋ 250 mL intravenous saline infusion, 1 times a day. The 2 groups were treated for 10 days as 1 course of treatment, after treatment the efficacy in the two groups was evaluated. Result： Significant efficiency was observed in observation group 62.50% , control group 45% （P 〈 0.05 ）. The total effective rate in observation group was 95%, control group 80% （P 〈0.05）. After treatment, AST, ALT, TBil, blood ammonia level in observation group were （143.93 ±75.41）, （124.45±74.43） U.L^-1, （155.92±71.21）, （131.43 ±49.16） μmol.L^-1; in control group they were respectively （113.75 ±70.58） U.L^-1, （94.32 ±42.64） U.L^-1,（117.31 ±61.23） , （91.33 -±39. 15） μmol. L^-1 , compared with before treatment in two groups of AST, ALT, TBil, blood ammonia levels decreased significantly （P 〈 0.05）, the observation group was improved more than control group （P 〈 0.05）. Fever, convulsions, consciousness disturbance, meningeal irritation, cranial nerve involvement disappearance time, EEG, cerebrospinal fluid to restore the normal time, the average hospitalization time in observation group were better than those in control group （P 〈 0.05 ）. Conclusion： The effect of Xingnaojing injection combined with reduced glutathione for treatment of hepatic encephalopathy is significant.

关 键 词：肝性脑病 醒脑静注射液 还原型谷胱苷肽 

分 类 号：R287[医药卫生—中药学]