联合应用间苯三酚与地屈孕酮治疗先兆流产的疗效分析  

Analyses of the curative effect of phloroglucinol combined with dydrogesterone in the treatment of threatened abortion

作　　者：孙定苗[1] 董梁[1] 

机构地区：[1]浙江省绍兴第二医院,绍兴312000

出　　处：《中国新药杂志》2012年第12期1381-1383,共3页Chinese Journal of New Drugs

基　　金：浙江省医药卫生科学研究计划重点项目(2010KYB117)

摘　　要：目的:分析联合应用间苯三酚与地屈孕酮治疗先兆流产患者的疗效。方法:将符合条件的先兆流产患者随机分成观察组与对照组各60例,观察组联合应用间苯三酚和地屈孕酮治疗,对照组仅用地屈孕酮治疗。对观察组与对照组的临床症状缓解及消失时间、继续妊娠率以及药物不良反应进行比较,出院后对患者进行随访,比较两组妊娠及分娩期并发症以及新生儿的不良结局。结果:观察组的继续妊娠率显著高于对照组。对照组临床症状缓解时间及消失时间均明显低于对照组。观察组出现胃肠道不适的患者明显少于对照组,差异均有统计学意义(P<0.05)。观察组和对照组妊娠及分娩期并发症和新生儿不良结局的差异不明显,差异无统计学意义。结论:联合应用间苯三酚与地屈孕酮治疗先兆流产疗效高于单纯使用地屈孕酮,药物不良反应少,建议临床推广。Objective： To analyze the clinical effect of phloroglucinol combined with dydrogesterone in the treatment of threatened abortion.Methods： The patients were randomly divided into 2 groups according to the inclusion criteria.The patients were treated with phloroglucinol combined with dydrogesterone or with dydrogesterone alone.The times of clinical symptom remission and disappearance,ongoing pregnancy rates and adverse drug reactions in the two groups were compared.Results： Compared with control group,the remission and disappear times of clinical symptoms shortened,the ongoing pregnancy rate increased and thegastrointestinal discomfort decreased in the combination group.The difference was statistically significant（P〈0.05）.Conclusion： The curative effect of phloroglucinol combined with dydrogesterone is better than that of dydrogesterone alone in the treatment of threatened abortion,with less adverse drug reactions.This can be recommended as a treatment option.

关 键 词：间苯三酚 地屈孕酮 先兆流产 

分 类 号：R977.1[医药卫生—药品]