曲美他嗪对不稳定型心绞痛患者疗效及校正QT离散度的影响  

Trimetazidine Efficacy and Its Effect on Corrected QT Dispersion in Patients with Unstable Angina Pectoris

作　　者：赵慧艳[1] 张福全[1] 

机构地区：[1]河南省安阳市人民医院心内科,455000

出　　处：《中国全科医学》2012年第16期1836-1838,共3页Chinese General Practice

摘　　要：目的探讨曲美他嗪对不稳定型心绞痛(UAP)患者疗效及校正QT离散度(QTcd)的影响。方法将78例UAP患者按随机数字表法分为曲美他嗪治疗组(38例)和非曲美他嗪治疗对照组(40例)。观察两组患者治疗前及治疗3个月后QTcd、心肌缺血、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、心血管事件发生情况及药物的不良反应。结果治疗3个月后两组患者的ST段下移幅度、T波倒置幅度、LVEF、LVEDD均比治疗前改善,差异有统计学意义(P<0.05);治疗3个月后治疗组的ST段下移幅度、T波倒置幅度、LVEF、LVEDD优于对照组,差异有统计学意义(P<0.05)。治疗1个月、3个月后治疗组QTcd均低于对照组,差异有统计学意义(P<0.05)。3个月内治疗组心血管事件发生率低于对照组,差异有统计学意义(P<0.05)。曲美他嗪无明显的不良反应。结论曲美他嗪可明显改善心肌缺血和左心室功能,降低UAP患者的QTcd和心血管事件发生率,改善患者的近期预后,且耐受性好,无明显的不良反应。Objective To investigate the effect of trimetazidine on the efficacy and corrected QT dispersion （QTcd） in patients with unstable angina pectoris. Methods Totally 78 patients with unstable angina pecton＇s were divided as trial group （ 38 cases） and control group （40 cases） according to the random number table. The patients in the trial received trimetazidine treat- ment, while those in the control group received non - trimetazidine treatment. The changes of QTcd, myocardial ischemia, left ventricular ejection fraction （LVEF） , left ventricular end -diastolic diameter （LVEDD） , cardiovascular events, and adverse drug reactions in the two groups before treatment and after 3 - month treatment were observed. Results After 3 - month treat- ment, the levels of amplitude of ST segment depression, T wave inversion amplitude, LVEF, and LVEDD of patients in the two groups were obviously improved （P 〈 0. 05 ） ; and the levels of amplitude of ST segment depression, T wave inversion amplitude, LVEF, and LVEDD of patients in the trial group were significantly better than those in the control group （ P 〈 0. 05 ）. QTcd of patients in the trial group was significantly lower than that in the control group after 1 - month and 3 - month treatment （ P 〈 0.05 ）. The incidence of cardiovascular events of patients in the trial group was significantly lower than that in the control group in the three months period （ P 〈 0. 05 ）. Trimetazidine induced no obvious adverse reactions. Conclusion Trimetazidine can sig- nificantly improve myocardial isehemia and left ventricular function, reduced QTcd and the incidence of cardiovascular events for patients with unstable angina pectoris. It can improve short - term prognosis of the patients, being well tolerated, and with no significant adverse reactions.

关 键 词：心绞痛 不稳定型 校正QT离散度 曲美他嗪 

分 类 号：R972.3[医药卫生—药品]