二甲基精氨酸与慢性肾脏病关系的研究进展  

Progression on the Relationship between Dimethylarginine and Chronic Kidney Disease

作　　者：胡天晓[1] 牛凯[1] 刘冰[1] 

机构地区：[1]河北省人民医院肾内科,河北省石家庄市050051

出　　处：《中国全科医学》2012年第18期2131-2134,共4页Chinese General Practice

基　　金：2011年医学科学研究重点课题(20110004)--<不对称二甲基精氨酸在慢性肾脏病诊治中作用的研究>

摘　　要：二甲基精氨酸是L-精氨酸的同系物,不对称性二甲基精氨酸作为一氧化氮合酶的抑制剂,因其能够降低一氧化氮水平进而影响内皮细胞的功能而备受关注。对称性二甲基精氨酸与L-精氨酸、不对称性二甲基精氨酸具有相同的细胞转运通路,可能对一氧化氮的合成存在间接的影响。肾脏作为二甲基精氨酸代谢的主要脏器,其结构和功能的改变会影响二甲基精氨酸的代谢。二甲基精氨酸水平的变化又会影响肾脏正常的生理功能。因此,二甲基精氨酸有可能作为慢性肾脏病进展的生物标志物。本文就其近期的研究情况做一综述。Dimethylarginine is a homologue of L - arginine. Asymmetric dimethylarginine, as an inhibitor of nitric ox- ide synthase, attracted much attention for their ability to affect endothelial cell function by reducing nitric oxide levels. Symmet- ric dimethylarginine, which have the same cellular transport pathway as L- arginine and asymmetric dimethylarginine, may im- pact indirectly on nitric oxide synthesis. As kidney plays an important role in dimethylarginine metabolism, its structural and functional changes will affect the metabolism of dimethylarginine. Also, the change of dimethylarginine levels will affect the nor- real physiological function of kidneys. Therefore, dimethylarginine may be used as biomarkers for advances in chronic kidney dis- ease. We will make a review on recent researches in this article.

关 键 词：慢性肾脏病 生物标志物 对称性二甲基精氨酸 不对称性二甲基精氨酸 

分 类 号：R692[医药卫生—泌尿科学]