血必净对油酸型急性肺损伤家兔血清炎症因子与肺水转运的影响  

Study of Serum Xuebijing Injection on Inflammatory Level and Lung Water Changes of Acute Lung Injury Rabbits Induced by Oleic Acid

作　　者：黄敏坚[1] 张远新[1] 李平[1] 

机构地区：[1]广州医学院第一附属医院,广东广州510120

出　　处：《中国医学创新》2012年第18期20-21,共2页Medical Innovation of China

摘　　要：目的:通过检测血必净注射液对油酸型急性肺损伤(ALI)家兔血清炎症因子与肺水转运的变化,探讨血必净对ALI的保护作用。方法:30只家兔随机分为三组,正常对照组、单纯急性肺损伤(ALI)组和血必净治疗组(油酸型ALI+血必净治疗),通过制备成油酸型急性肺损伤(ALI)家兔模型后,即进行血必净静脉注射,观察不同时段血清炎症因子(TNF-α、IL-6)的变化及检测左肺叶组织湿质量/干质量(W/D)值。结果:油酸致伤后1h、12h、24h、36h、48h血清TNF-α、IL-6浓度显著增高,尤其以TNF-α增幅最大,应用血必净注射液后与对照组比较血清TNF-α、IL-6活性明显改善(P<0.05),W/D值明显下降,渗出减轻。结论:炎症因子在油酸型急性肺损伤(ALI)过程中起重要作用,血必净注射液可能通过抑制TNF-α、IL-6过量分泌,减轻肺损伤,具有防治ALI作用,可有效缓解油酸所致肺损伤。Objective：To study the effect of Xuebijing Injection on serum inflammatory and lung water changes of acute lung injury （ALI）induced by oleic acid, to evaluate protective effect of Xuebijing in the the ALi.Methods：30 rabbits were randomly divided into 3 groups, normal control group, acute lung injury （ALI） group and treatment group.Treatment group were given Xuebijing injection after preparation of rabbits model of ALI induced by oleic acid.The chage of serum inflammatory factor （TNF-A, IL-α） in different periods was observed and wet weight/dry weight（W/D）of left lobe tissue was detected.Results： I, 12, 24, 36, 48 hours after injury induced by oleic acid, the levels of serum TNF, IL-α were significantly increased, especially in TNF. Compared to control group, levels, of serum TNF, IL-α were significantly improved after treatment with Xuebijing injection （P 〈0.05）, W/D was decreased.Conclusion：Inflammation factor may plays an important role on ALI induced by oleic acid.It can effectively alleviate acute lung injury induced by oleic acid through inhibit excessive secretion of TNF-a and IL-α.

关 键 词：血必净注射液 急性肺损伤 炎症因子 肺水转运 

分 类 号：R285.5[医药卫生—中药学]