前列腺素E1脂微球制剂治疗老年慢性心功能不全患者的疗效评价  

Evaluation of the Effect of Lipo-prostaglandin E1 on Elderly Patients with Chronic Heart Failure by 6-minute Walk Test

作　　者：徐勇[1] 李榕彬[1] 智光[1] 周肖[1] 冯斌[1] 付振虹[1] 刘峻松[1] 

机构地区：[1]解放军总医院海南分院心内科,海南三亚572000

出　　处：《解放军药学学报》2012年第3期222-224,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：863课题心血管疾病多参数监测微系统;No.2007AA042105

摘　　要：目的用6 min步行试验评价前列腺素E1脂微球制剂辅助治疗老年慢性心功能不全患者的效果。方法我院住院老年患者经常规抗心衰药物治疗5～7 d,病情相对稳定,NYHA心功能分级在Ⅱ级-Ⅳ级,入选的患者随机分组,最终收集资料完整患者235名,其中治疗组109例、对照组126例。治疗组用前列腺素E1脂微球制剂20μg静脉滴注,1次/d,14 d为1疗程。对照组除不用前列腺素E1脂微球制剂外,其他治疗与治疗组相同。治疗前后测定6 min步行距离,左心室舒张末期内径(LVEDd)、左心室收缩末期内径(LVESd)、左心室射血分数(LVEF),比较其结果。结果治疗组治疗前后6 min步行距离、LVESd、LVEF有显著性差异,而对照组治疗前后6 min步行距离有显著性差异,LVEDd、LVESd、LVEF无显著性差异;两组之间在治疗前无显著性差异,治疗后治疗组6 min步行距离、LVESd较对照组明显改善、LVEDd、LVEF两组之间无显著性差异。两组间药物不良反应无显著性差异。结论前列腺素E1脂微球制剂在常规治疗的基础上还能进一步明显提高老年心功能不全患者6 min步行距离,改善心功能,且不良反应少。Objective To evaluate the clinical effect of lipo-prostaglandin E1 on patients with chronic heart failure（CHF） by 6-minute walk test（6 MWT）.Methods All the subjects were aged in patients with CHF,who received regular anti-heart failure therapy for 5-7 d.They were randomly divided into treatment group（109 cases） and control group（126 cases） after clinic conditions became stable.The treatment group was given additional lipo-prostaglandin E1 20 μg intravenous infusion,qd,with 14 d as a treatment course.All the subjects continued to be treated with regular anti-heart failure medication.Before and after 2-week treatment,patients were asked to do 6 MWT and echocardiography（LVEDd,LVESd,LVEF were measured）.Results There was significant difference in 6 MWT,LVEDd,LVESd and LVEF in treatment group after 2-week lipo-prostaglandin E1 infusion,compared to before medication.However,there was no significant difference in those parameters in control group before and after 2-week regular medication.6 MWT and LVESd in treatment group after 2-week lipo-prostaglandin E1 medication exhibited significant improvement,compared to those in control group after 2-week regular medication.The side-effect of lipo-prostaglandin E1 was negligible.Conclusion Lipo-prostaglandin E1 can further improve 6 MWT and cardiac function among elder patients with CHF after regular anti-heart failure therapy.The side-effect of lipo-prostaglandin E1 can be ignored.

关 键 词：前列腺素E1脂微球制剂 慢性心力衰竭 6min步行试验 

分 类 号：R541[医药卫生—心血管疾病]