制霉素分散片的制备  

Preparation of Nystatin Dispersible Tablets

作　　者：付桂英[1] 李秀青[1] 孙燕[1] 李丽华[1] 温明铃[1] 

机构地区：[1]解放军307医院药学部,北京100071

出　　处：《解放军药学学报》2012年第3期229-231,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的制备服用方便,稳定性好的制霉素分散片。方法通过筛选崩解剂,采用粉末直接压片工艺制备制霉素分散片,以崩解时限、混悬性等因素为指标,通过正交实验对处方进行筛选。结果优选处方中崩解剂为微晶纤维素30%,可压性淀粉7%,交联聚维酮5%。对优选处方的实验表明:崩解时限小于3 min:分散均匀性和混悬性较好。结论优选处方制备的制霉素分散片达到了分散片的质量要求。Objective To prepare nystatin dispersible tablets with applicability quick action. Methods Dis- integrants were screened. Direct powder compression technique was used to prepare nystatin dispersible tablets. The prescription was assessed in terms of disintegration time and suspension stability. Results An optimal prescription assembly was 30% of MCC ,7% of PVPP,5% of PVPP. The test showed that disintegration time was less than three minutes, dispersity was homogenious and suspension was stable. Conclusions The nystatin dispersible tablets with optimal prescription can meet dispersible tablet requirements.

关 键 词：制霉素 分散片 制备 

分 类 号：R944[医药卫生—药剂学]