偏痛胶囊流浸膏对血液流变学、血栓形成及脑电图的影响  

Effects of PIANTONG capsule fluid extract on hemorheology,thrombus formationin vitroand electroencephalogram of pain-stimulated animals

作　　者：徐暾海[1] 文萍[1] 刘斌[1] 张小勇[1] 贾萧容[1] 陶晓华[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国临床药理学与治疗学》2012年第6期601-608,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：北京市教育委员会科技成果转化与产业化项目

摘　　要：目的:研究偏痛胶囊流浸膏对肾上腺素致血瘀模型大鼠血液流变学、家兔体外血栓形成及其疼痛刺激模型大鼠脑电图的影响。方法:肾上腺素联合冰水游泳法复制大鼠血瘀模型,观察偏痛胶囊对血瘀模型大鼠血液流变学的影响,体外血栓法观察偏痛胶囊流浸膏对正常家兔血栓形成的影响,脑电图法分析偏痛胶囊流浸膏对疼痛模型大鼠脑电频率和振幅的影响。结果:偏痛胶囊流浸膏可明显降低血瘀模型大鼠血液高切、低切黏度、全血还原黏度及血浆黏度(P<0.01或P<0.05),抑制家兔体外血栓的形成(P<0.01或P<0.05),表现为较好的活血化瘀、抗血栓作用;同时,偏痛胶囊流浸膏还可明显抑制大鼠足底辐射热刺激引起的δ频段百分下降(P<0.05),α2、α3频道百分比升高(P<0.05)等病理性脑电图变化,表现为较好的镇痛作用。结论:偏痛胶囊流浸膏可明显改善血液流变学,具有良好的抗血栓作用,同时可明显减弱疼痛引起的大鼠脑电图的异常变化。AIM.. To investigate the influence of PIANTONG capsule fluid extract on hemo- theology, thrombus formation in vitro and elec- troeneephalographic waves of rats induced by pain stimulation. METHODS： Duplicated the blood stasis animal model with adrenine injection and cold water swimming, observed the effect of PIANTONG capsule fluid extract in treating he- morheology, anti-thrombus in vitro, and electroencephalogram. RESULTS. The fluid extract of PIANTONG capsule fluid extract decreased the whole blood high shear viscosity and low shear viscosity, whole blood reduced viscosity and plasma viscosity （P〈0.01 or P%〈. 05） of rats blood stasis model, inhibited the thrombus formation of rabbits in vitro （P〈0. O1 or P〈0.05）, showed better anti-thrombus effect. At the same time, the fluid extract of PIANTONG capsule inhibited the change of electroencephalogram（EEG） which were induced by radiant heat of rat footplate, such as the ratio of 8, a2 and aa frequency （P〈0.05）, indicated that it has anal- gesic effect. CONCLUSION. PIANTONG capsule improved hemorrheology of rats, showed upstanding anti-thrombus effects, and manifestly attenuated the abnormal changes of EEG which was induced by pain.

关 键 词：偏痛胶囊 流浸膏 血液流变学 血栓形成 脑电图 

分 类 号：R965.2[医药卫生—药理学]