胆囊疾病与冠状动脉粥样硬化性心脏病的相关性及危险因素分析  

Association between gallbladder disease and coronary heart atherosclerotic disease and risk factors for gallbladder disease

作　　者：孙露萤[1] 蒋兆彦[2] 杨肖波[1] 徐琛莹[1] 常显星[1] 李薇薇[1] 俞丽芬[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院消化科,上海200025 [2]上海交通大学医学院附属瑞金医院上海消化外科研究所,上海200025

出　　处：《上海交通大学学报（医学版）》2012年第6期756-760,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金项目(81070367)~~

摘　　要：目的分析胆囊疾病(GBD)与冠状动脉粥样硬化性心脏病(CAD)的关系及相关危险因素。方法回顾性分析经冠状动脉造影明确的CAD患者(CAD组,n=712)和冠状动脉无狭窄的疑似CAD者(对照组,n=571)的临床资料,比较两组GBD的患病率,采用Logistic回归分析体质量指数(BMI)、腰围、高血脂及糖尿病与GBD的相关性。结果 CAD组中GBD的患病率显著高于对照组(37.5%和25.6%,P<0.01)。单因素和多因素Logistic回归分析均显示,男性GBD与CAD具有显著相关性(OR=1.32,95%CI:1.17～1.49,P<0.01),女性CAD与GBD无显著相关性。BMI、高血压史、高血脂史和糖尿病史是与GBD相关的危险因素。结论男性GBD与CAD具有显著相关性。Objective To investigate the association between gallbladder disease（GBD） and coronary atherosclerotic heart disease（CAD）,and explore the related risk factors for GBD.Methods The clinical data of patients with CAD（CAD group,n=712） and those suspected of CAD without stenosis of coronary artery（control group,n=571） confirmed by coronary angiography were retrospectively analysed.The prevalence of GBD was compared between two groups,and the association of body mass index（BMI）,waist circumference,hyperlipidemia and diabetes with GBD was explored by Logistic regression analysis.Results The prevalence of GBD in CAD group was significantly higher than that in control group（37.5% vs 25.6%,P〈0.01）.Univariate and multivariate Logistic regression analysis revealed that CAD was significantly related to GBD for males（OR=1.32,95%CI：1.17-1.49,P〈0.01）,but not significantly related to GBD for females.BMI,history of hypertension,hyperlipidemia and diabetes were risk factors for GBD.Conclusion GBD is significantly related to CAD for males.

关 键 词：胆囊疾病 冠状动脉粥样硬化性心脏病 高血脂 糖尿病 

分 类 号：R541.4[医药卫生—心血管疾病]