活血化瘀消癥杀胚中药对输卵管妊娠部位黏膜细胞超微结构的影响  

Study on the Ultrastructural Morphology Changes of Pregnanted Oviduct Epithelial Cells after Using the Chinese Medicine which Activate Blood,Dissolve Stasis,Eliminate Mass and Kill Embryo

作　　者：孙佳琦[1] 袁烁[1] 邓高丕[1] 

机构地区：[1]广州中医药大学第一附属医院,广东广州510405

出　　处：《云南中医学院学报》2012年第3期32-36,共5页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：广东省科技计划项目(粤科社字[2006]122号-63013)

摘　　要：目的:从输卵管黏膜超微结构影响的角度探讨中药治疗输卵管妊娠的作用机理。方法:收集20例输卵管妊娠患者手术切除的输卵管组织进行电镜检测。观察组10例为口服活血化瘀消癥杀胚中药3天后手术切除的妊娠输卵管组织,对照组10例为未经任何药物治疗直接进行手术切除的妊娠输卵管组织。结果:活血化瘀消癥杀胚中药能使输卵管粘膜上皮细胞纤毛微绒毛、线粒体、细胞核、内质网均发生明显改变(P<0.05),而两组的胞内空泡比较无显著性差异(P>0.05)。结论:活血化瘀消癥杀胚中药可能通过改变妊娠输卵管黏膜细胞的超微结构,影响妊娠输卵管黏膜细胞的生理代谢过程,进而促进胚胎组织的消亡。Objective： To discuss the mechanism of the Chinese medicine, which activate blood, dissolve stasis, eliminate mass and kill embryo in treating the fallopian pregnancy, from the point of the ultrastructural morphology changes of pregnanted oviduct epithelial ceils. Method： Collecting 20 fallopian tissues of the ectopic pregnancy patients, 10 of which took the Chinese medicine that activate blood, dissolve stasis, eliminate mass and kill embryo in treating the fallopian pregnancy for 3 days before salpingectomy. 10 of which were treated by salpin- gectomy directly without taking any medicine. Result： There is significant difference in the cilia microvilli, mitochondria, nucleus, endoplasmic reticulum structure after using Chinese medicine, （P 〈 0. 05, separately）. There is not statistically significant difference in intracellular vacuoles between the two groups （ P 〉 0. 05 ）. Conclusion ： It hints that the Chinese medicine, which activate blood, dissolve stasis, eliminate mass and kill embryo, can affect the physiology metabolism process pathway of the fallopian tube ceils.

关 键 词：活血化瘀消癥杀胚中药 输卵管妊娠 输卵管粘膜 超微结构 电镜 

分 类 号：R285.5[医药卫生—中药学]