含氟苯并噻唑基双酰胺衍生物合成及生物活性  

Synthesis and Biological Activity of Anthranilic Diamides Compounds Containing Fluorine and Benzothiazole Unites

作　　者：薛伟[1] 李海畅[1] 范会涛[1] 熊壮[1] 何勇[1] 祁慧雪[1] 

机构地区：[1]教育部绿色农药与农业生物工程重点实验室,贵州大学精细化工研究开发中心,贵州贵阳550025

出　　处：《济南大学学报（自然科学版）》2012年第4期353-357,共5页Journal of University of Jinan(Science and Technology)

基　　金：国家自然科学基金(21062005);贵州大学引进人才科研基金(201122)

摘　　要：含氟苯甲酸经酰氯化后与邻氨基苯甲酸反应,在醋酸酐中闭环后与取代苯并噻唑胺反应,合成10个含氟基苯并噻唑基邻甲酰氨基苯甲酰胺类化合物。其结构经核磁碳谱、氢谱、红外及元素分析确证。生物活性测试结果表明:当目标化合物质量浓度在500 mg/L时,Ⅳ2和Ⅳ10对烟草花叶病毒(TMV)的抑制率分别为44.5%和45.1%。Ten novel anthranilic diamides compounds containing fluorine and benzothiazole compounds were sythesized after benzoic acid containing fluorine unite chloridized by thionyl then coupled with 2-aminobenzoic acid, and cyclized in the existence of acetic anhydride, then coupled with substituted benzo [ d ] thiazol-2-arnine. Their structures were characterized by l HNMR, 13C NMR, IR and elemental analyses. The results of bioassay showed that in the concentration of 500 mg/L,the inhibition rates of compound 1V2 and IV10 against tobacco mosaic virus （TMV） were 44.5 % and 45.1%, respectively.

关 键 词：邻甲酰氨基苯甲酰胺 苯并噻唑 氟 烟草花叶病毒 

分 类 号：O626[理学—有机化学]