蚓激酶对30周糖尿病模型大鼠胃肌间丛神经元尼氏体的影响  

The effect of Lumbrokinase on the neuron Nissl bodies in the gastric muscle plexus of diabetic rats

作　　者：陆英杰[1] 连至诚[2] 钟毅 赵自明[4] 

机构地区：[1]佛山科学技术学院动物医学系,广东佛山528231 [2]广州中医药大学脾胃研究所,广东广州510405 [3]广州第二中医院,广东广州510400 [4]广东省中医研究所,广东广州510400

出　　处：《佛山科学技术学院学报（自然科学版）》2012年第3期79-81,共3页Journal of Foshan University(Natural Science Edition)

摘　　要：应用链脲佐菌素(Streptozotocin,STZ)建立SPF级SD大鼠糖尿病模型,糖尿病大鼠随机分为蚓激酶干预组和模型组。实验持续30周后,采用甲苯胺蓝染色方法对糖尿病30周大鼠、正常对照组及蚓激酶干预组的胃肌间丛神经元尼元氏体进行检测。结果:糖尿病30周模型大鼠尼氏体数量比正常组少(P<0.01);而蚓激酶组数量较模型组多(P<0.01)与正常组之间有差异(P<0.05)。结论:实验30周糖尿病模型大鼠胃肌间丛尼氏体数量减少,显示神经损害;蚓激酶组尼氏体数量较多,显示蚓激酶的保护作用。Objective To observe the treatment effect of Lumbrokinase on the neuron Nissl bodies in the gastric muscle plexus of diabetic rats. Methods An experiment on the SPF models established by using streptozotocin （STZ） and diabetic rats which were randomly put into the control and the I.umbrokinase trial groups was carried out. The effect was examined through the use of toluidine in 30 weeks. Results The amount of neuron Nissl bodies of the models was less than that of the control group （P〈0. 01） while the amount of neuron Nissl bodies of the Lumbrokinase trial group was more than that of the models （P〈0. 01）. There was a difference between the control and the trial groups （P〈0. 05）. Conclusion The decrease of the amount of neuron Nissl bodies of the models indicated the neuron was damaged and Lumbrokinase was effective in protecting neuron.

关 键 词：胃肌间丛 神经元尼氏体 糖尿病大鼠 蚓激酶 

分 类 号：R587.1[医药卫生—内分泌]