BF_3·Et_2O promoted conjugate addition of ethanethiol to electron-deficient alkynes  

作　　者：Qing Fa Zhou Xue Ping Chu Shen Zhao Tao Lu Wei Fang Tang 

机构地区：[1]Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China

出　　处：《Chinese Chemical Letters》2012年第6期639-642,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.21102179);Fundamental Research Funds for the Central Universities(No.JKZ2011011) for the financial support

摘　　要：An effective method for the synthesis of vinyl thioethers through the conjugate addition of ethanethiol to electron-deficient alkynes promoted by BF3.Et20 has been developed. Electron-deficient internal alkynes react with ethanethiol in this system to yield mainly Z-isomer of vinyl thioether adducts, while electron-deficient terminal alkynes afford mainly E-isomer of vinyl thioether adducts.An effective method for the synthesis of vinyl thioethers through the conjugate addition of ethanethiol to electron-deficient alkynes promoted by BF3.Et20 has been developed. Electron-deficient internal alkynes react with ethanethiol in this system to yield mainly Z-isomer of vinyl thioether adducts, while electron-deficient terminal alkynes afford mainly E-isomer of vinyl thioether adducts.

关 键 词：Vinyl thioether Electron-deficient alkyne Conjugate addition SYNTHESIS 

分 类 号：O562.5[理学—原子与分子物理] TQ325.15[理学—物理]