Tri-n-butylphosphane catalyzed ring opening of aziridines with secondary amines  

作　　者：Wan Xuan Zhang Li Su Wei Gang Hu Jie Zhou 

机构地区：[1]Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, China

出　　处：《Chinese Chemical Letters》2012年第6期657-660,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.20872031)

摘　　要：Ring opening of aziridine with dialkyl amine took place readily in the presence of catalytic amounts of tri-n-butylphosphane （10 mol%） in the mixture of CH3CN/H20 （10：1）, giving corresponding vicinal diamines in mediate to high yields （58-95%） with good regioselectivitie, while aromatic secondary amine could not react under the same conditions. Tri-n-butylphosphane exhibited different catalytic selectivity to amines from Lewis acid catalysts.Ring opening of aziridine with dialkyl amine took place readily in the presence of catalytic amounts of tri-n-butylphosphane （10 mol%） in the mixture of CH3CN/H20 （10：1）, giving corresponding vicinal diamines in mediate to high yields （58-95%） with good regioselectivitie, while aromatic secondary amine could not react under the same conditions. Tri-n-butylphosphane exhibited different catalytic selectivity to amines from Lewis acid catalysts.

关 键 词：AZIRIDINES Ring-opening reaction Secondary amine Tfi-n-butylphosphane Vicinal diamine 

分 类 号：TQ226.38[化学工程—有机化工] O643.36[理学—物理化学]