Facile and efficient synthesis of 5,7-disubstituted thiazolo[5,4-d] pyrimidine-4,6(5H,7H)-diones  

作　　者：Liang Chen Zhan Mei Li Jie Zhou Hong Rui Song Bai Ling Xu 

机构地区：[1]Beifing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute ofMateria Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050, China [2]Department of Pharmacy Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China

出　　处：《Chinese Chemical Letters》2012年第6期695-698,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.30500634) and NSF of Beijing (No.7102112)

摘　　要：A facile and efficient approach was developed to access 5, 7-disubstitued thiazolo[5,4-d]pyrimidine-4, 6（5H, 7H）-diones through condensation of N-substituted 5-amino-4-carbethoxythiazole with structurally diverse isocyanates in the presence of sodium hydride. The easy availability of substrates and tolerance of structural diversity in this reaction make it attractive to be used for construction of libraries in drug discovery process.A facile and efficient approach was developed to access 5, 7-disubstitued thiazolo[5,4-d]pyrimidine-4, 6（5H, 7H）-diones through condensation of N-substituted 5-amino-4-carbethoxythiazole with structurally diverse isocyanates in the presence of sodium hydride. The easy availability of substrates and tolerance of structural diversity in this reaction make it attractive to be used for construction of libraries in drug discovery process.

关 键 词：Thiazolo[5 4-d]pyrimidine-4 6（5H 7H）-dione ISOCYANATE ISOTHIOCYANATE Sodium hydride 

分 类 号：O626.41[理学—有机化学] TQ252.5[理学—化学]