载脂蛋白B48研究进展  

Research Progress of Apolipoprotein B48

作　　者：黄微[1,2] 刘瑞[1] 

机构地区：[1]四川大学华西医院生物治疗国家重点实验室人类疾病相关多肽研究室 [2]四川大学华西医院消化内科,四川省成都市610041

出　　处：《中国动脉硬化杂志》2012年第7期668-672,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金(30870919)

摘　　要：载脂蛋白B48主要由小肠合成,参与乳糜微粒的组装、代谢,是食物脂肪吸收中不可缺少的蛋白。其表达量受多种因素影响。异常表达可导致小肠脂代谢异常,进而导致肥胖发生和动脉粥样硬化等疾病。本文主要针对载脂蛋白B48相关研究进行综述。Apolipoprotein B48（ApoB48） is mainly synthesized by intestine epithelial cells,and involved in the assembly and metabolism of chylomicrons.It has an obligatory role in the intestinal absorption of dietary fats.Expression of ApoB48 can be regulated by a variety of factors.The abnormal expression of ApoB48 may lead to disorder of lipid metabolism in the intestine.This may lead to obesity and atherosclerosis eventually.We mainly review the recent progress in the study of ApoB48.

关 键 词：载脂蛋白B48 动脉粥样硬化 肥胖 

分 类 号：R34[医药卫生—基础医学]